扬州市2013-2015年梅毒母婴传播阻断工作临床干预情况

发布时间：2018-01-14 14:00

本文关键词：扬州市2013-2015年梅毒母婴传播阻断工作临床干预情况　出处：《中国艾滋病性病》2017年12期 　论文类型：期刊论文

【摘要】：目的了解近3年扬州市预防梅毒母婴传播工作的实施情况,探讨临床干预的时机、药物对妊娠结局和先天梅毒的影响,为今后梅毒母婴阻断工作提供科学依据。方法整理2013-2015年扬州市预防梅毒母婴传播的网络数据,对妊娠梅毒及新生儿梅毒案例进行分析。结果 2013-2015年,孕产妇总数114 136人,梅毒阳性人数317人,阳性率0.28%。梅毒孕产妇生产先天梅毒新生儿3人。317名妊娠梅毒患者按孕早期和孕中晚期治疗时间分组,不良妊娠结局分别为1.6%和7.6%(χ~2=7.08,P0.01);按青霉素类及非青霉素类治疗药物分组,不良妊娠结局分别为2.0%和46.7%(χ~2=72.61,P0.01);按是否规范治疗分组,不良妊娠结局分别为1.1%和22.2%(χ~2=38.59,P0.01);三组不良妊娠结局对比,差异均有统计学意义。结论对妊娠期梅毒患者的早期诊断、青霉素规范治疗,可显著改善妊娠结局,减少先天梅毒的发生;妊娠期及新生儿的定期监测随访以及高危儿预防性治疗不可忽视。
[Abstract]:Objective to understand the implementation of Yangzhou city in the past 3 years to prevent the spread of syphilis work, to investigate the clinical effect of drug intervention time on the outcome of pregnancy and congenital syphilis, and provide scientific basis for the future work of the network data. Methods PMTCT of syphilis in Yangzhou city to prevent syphilis 2013-2015 mother to child transmission of syphilis, pregnancy and neonatal syphilis cases were analyzed. Results in 2013-2015, the total number of 114136 syphilis positive pregnant women, the number of 317, the positive rate of 0.28%. syphilis maternal production of neonatal congenital syphilis 3.317 pregnant syphilis patients in late pregnancy and early pregnancy treatment time group, adverse pregnancy outcomes were 1.6% and 7.6% (~2=7.08, P0.01); according to penicillins and non penicillin drug treatment group, adverse pregnancy outcomes were 2% and 46.7% (~2=72.61, P0.01); according to whether the standard treatment group, adverse pregnancy outcomes respectively. 1.1% and 22.2% (~2=38.59, P0.01); the three groups of adverse pregnancy outcomes compared, the differences were statistically significant. Conclusion the early diagnosis of syphilis in pregnancy, penicillin standardized treatment can significantly improve the outcome of pregnancy, reduce the incidence of congenital syphilis; during pregnancy and neonatal follow-up and regular monitoring of high-risk infants preventive treatment can not be ignore.

【作者单位】：扬州大学医学院附属医院扬州市妇幼保健院皮肤科;
【分类号】：R759.15
【正文快照】： 近年来梅毒的发病越来越隐匿,尤其是妊娠期梅毒、隐性梅毒的患者越来越多,因此,预防梅毒母婴传播成了全社会共同关注的公共卫生问题[1-2]。妊娠梅毒的感染可以在妊娠前或妊娠过程中,其严重性不仅危害孕妇的健康,还可通过垂直传播感染胎儿,造成流产、早产、死胎、新生儿梅毒等

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