50例隐球菌血症的临床与预后分析

发布时间：2018-01-15 05:29

本文关键词：50例隐球菌血症的临床与预后分析　出处：《浙江大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的：探讨不同免疫状态人群隐球菌血症的临床特点。方法：对浙江大学医学院附属第一医院(2002年12月至2014年3月)50例隐球菌血症的临床资料进行回顾性分析,根据患者自身免疫情况分成免疫缺陷组(41例)和免疫健全组(9例),对研究病例的性别、发病年龄、临床表现、实验室检查、抗真菌药物及疗效进行分析。结果：50例隐球菌血症中男性30例,女性20例,年龄15-83岁,平均(49-3：17.0)岁；43例有不同程度发热表现,性别、年龄、平均住院时间、临床表现、白细胞、中性粒细胞比例、C反应蛋白、尿素氮等在两组中差异无统计学意义,免疫缺陷组患者合并隐球菌性脑膜炎、同时合并隐球菌性脑膜炎及肺隐球菌病的病例高于免疫健全组。住院期间死亡10例,病情恶化13例,好转27例。结论：隐球菌血症的临床表现不典型,免疫缺陷组较免疫健全组易引起隐球菌血症,免疫缺陷组更易合并隐球菌性脑膜炎及肺隐球菌病,隐球菌血症的预后差。
[Abstract]:Objective: to investigate the clinical characteristics of Cryptococcinemia in different immune states. Methods: the first affiliated Hospital of Zhejiang University Medical College (December 2002 to March 2014). The clinical data of 50 cases of Cryptococcinemia were analyzed retrospectively. According to the autoimmune status of the patients, 41 patients were divided into the immune deficiency group (n = 41) and the immune healthy group (n = 9). The sex, age of onset, clinical manifestation and laboratory examination of the patients were studied. Results of 50 cases of Cryptococcosis, 30 cases were male, 20 cases were female, the age was 15-83 years old, the average age was 49-3: 17.0 years old; There was no significant difference in fever, sex, age, average hospitalization time, clinical manifestation, leukocyte, neutrophil ratio of C reactive protein and urea nitrogen between the two groups. The cases of cryptococcal meningitis, cryptococcal meningitis and pulmonary cryptococcosis in the immunodeficient group were higher than those in the healthy immune group. Conclusion: the clinical manifestation of Cryptococcinemia is not typical, the immune deficiency group is more likely to cause cryptococcal disease than the immune healthy group, and the immune deficiency group is more likely to be associated with cryptococcal meningitis and pulmonary cryptococcosis. The prognosis of Cryptococcinemia is poor.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R519.4

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