维生素D受体基因SNP rs2222570多态性与河南人群肺结核病易感性研究

发布时间：2018-01-15 12:13

本文关键词：维生素D受体基因SNP rs2222570多态性与河南人群肺结核病易感性研究　出处：《现代预防医学》2017年13期 　论文类型：期刊论文

【摘要】：目的调查河南地区维生素D受体(VDR)基因SNP位点rs2222570和结核病易感性之间关系。方法研究采用以医院为基础的病例对照研究方法,病例组纳入260个结核菌菌阳患者,并以年龄和性别相匹配纳入258名健康体检人群作为对照组。采用聚合酶链式反应-限制性片段长度多态性对VDR基因SNP位点rs2222570多态性进行分析。结果在本次研究中258例对照人群中VDR基因C/C,C/T和T/T三种基因型分别占110(42.6%),106(41.1%),42(16.3%);在260例结核病患者中VDR基因C/C,C/T and T/T三种基因型分别占70(26.9%),130(50%),60(23.1%),二者分布存在统计学差异(=14.499,P=0.001)。单因素分析表明VDR基因SNP位点rs2222570多态性与结核病患病风险相关,VDR基因野生型C/C与杂合型C/T和突变型T/T相比降低了结核病发病50%的风险(校正OR=0.496,95%CI:0.344-0.717)。结论在河南地区VDR受体基因多态性与结核病发病相关。
[Abstract]:Objective to investigate the Henan area of the vitamin D receptor (VDR) gene SNP polymorphism and the relationship between the rs2222570 susceptibility of tuberculosis. Methods on a hospital-based case-control study method, case group included 260 TB smear positive patients, and matched by age and gender in 258 healthy subjects as the control group. Using polymerase chain reaction restriction fragment length polymorphism analysis of VDR gene SNP rs2222570 polymorphism. The results in this study, 258 cases of control group in VDR gene C/C, C/T and T/T three genotypes respectively accounted for 110 (42.6%), 106 (41.1%), 42 (16.3%); in 260 cases of TB patients in VDR C/C C/T and T/T gene, three genotypes accounted for 70 (26.9%), 130 (50%), 60 (23.1%), there was a significant difference between the two distributions (=14.499, P=0.001). Single factor analysis showed that the VDR gene SNP rs2222570 polymorphism and tuberculosis The risk of VDR gene wild type C/C is lower than that of heterozygous C/T and mutant T/T. It reduces the risk of TB 50% (corrected OR=0.496,95%CI:0.344-0.717). Conclusion the polymorphism of VDR receptor gene is associated with the incidence of tuberculosis in Henan area.

【作者单位】：河南省疾病预防控制中心;
【分类号】：R181.3;R521
【正文快照】： 据WTO统计,目前全球感染者约占全球总人口的三分之一,每天约有8000人死于结核病,每年约有300万人死于结核病。中国作为结核病高负担国家,每年有100万人发病[1]。尽管结核病作为一种高度传染性疾病,但结核菌携带者中只有十分之一的发病,结核分枝杆菌的感染、结核病的发生和转归

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