克拉霉素与阿奇霉素和多西环素在生殖道衣原体感染患者中的疗效

发布时间：2018-01-16 00:15

本文关键词：克拉霉素与阿奇霉素和多西环素在生殖道衣原体感染患者中的疗效　出处：《中华医院感染学杂志》2017年17期 　论文类型：期刊论文

【摘要】：目的比较克拉霉素与阿奇霉素、多西环素在生殖道衣原体感染患者中的疗效,为临床治疗提供理论依据。方法选择2015年1月-2016年1月在医院就诊的生殖道衣原体感染患者124例,按照随机数表法将患者分为三组,克拉霉素组(A组)42例、阿奇霉素组(B组)41例、多西环素组(C组)41例;三组患者均连续用药2周,治疗2周后进行疗效评价,根据患者的临床体征进行疗效判定,统计三组患者症状改善时间和衣原体清除率及不良反应发生情况。结果 A组治疗有效率为92.86%,B组治疗有效率为78.05%,C组治疗有效率为73.17%,A组患者的治疗有效率显著高于B组和C组,差异有统计学意义(P0.05);A组患者阴转例数为39例,衣原体清除率为92.86%,症状改善时间为(7.49±4.03)d,B组患者阴转例数为32例,衣原体清除率为78.05%,症状改善时间为(11.03±4.93)d,C组患者阴转例数为30例,衣原体清除率为73.17%,症状改善时间为(12.37±4.85)d,A组患者的阴转例数和衣原体清除率显著高于B组和C组,症状改善时间显著短于B组和C组(P0.05),A组不良反应发生率为4.76%,B组不良反应发生率为7.32%,C组不良反应发生率为9.76%,A组患者不良反应发生率显著低于B组和C组(P0.05)。结论克拉霉素对生殖道衣原体感染的治疗具有较好的临床效果,且具有较好的安全性。
[Abstract]:Objective to compare the efficacy of clarithromycin with azithromycin and doxycycline in patients with genital chlamydia infection. Methods 124 patients with genital chlamydia infection from January 2015 to January 2016 were selected and divided into three groups according to the method of random number. Clarithromycin group (n = 42), azithromycin group (n = 41) and doxycycline group (n = 41). Three groups of patients were treated continuously for 2 weeks, after 2 weeks of treatment to evaluate the efficacy, according to the clinical signs of patients to determine the efficacy. Results the effective rate of treatment in group A was 92.86% and the effective rate of group B was 78.05%. The effective rate of group C was 73.17 and the effective rate of group A was significantly higher than that of group B and C (P 0.05). There were 39 cases of negative conversion, 92.86% of clearance rate of chlamydia and 32 cases of negative conversion in group B with symptom improvement time of 7.49 卤4.03d. The clearance rate of chlamydia was 78.05, the time of symptom improvement was 11.03 卤4.93 DX group (30 cases) and the clearance rate of chlamydia was 73.17% cases. The number of negative cases and the clearance rate of chlamydia in group A were significantly higher than those in group B and C, and the time of symptom improvement was significantly shorter than that in group B and group C (P 0.05). The incidence of adverse reactions in group A was 4.76 and that in group B was 7.320.The incidence of adverse reactions in group C was 9.76%. The incidence of adverse reactions in group A was significantly lower than that in group B and group C. conclusion clarithromycin has better clinical efficacy and safety in the treatment of chlamydia gondii infection.
【作者单位】：铜仁市人民医院药学部;铜仁市人民医院妇产科;铜仁市人民医院男科;
【基金】：贵州省铜仁市科学技术基金项目[铜市科研(2014)77-4号]
【分类号】：R518
【正文快照】： 衣原体是细胞内寄生的微生物,近年来生殖道衣原体感染率呈不断上升趋势,沙眼衣原体是引起生殖器官感染的主要病原菌[1-2]。生殖道衣原体感染主要通过性接触传播,临床症状轻微,但是患者的身心健康会受到严重影响,沙眼衣原体的耐药性也不断提高[3]。临床治疗生殖道衣原体感染的

【相似文献】