OPN基因启动区-156delG多态性与中国HBV相关肝细胞癌的易感性

发布时间：2018-01-16 05:02

本文关键词：OPN基因启动区-156delG多态性与中国HBV相关肝细胞癌的易感性　出处：《中山大学学报(医学科学版)》2017年05期 　论文类型：期刊论文

【摘要】：【目的】研究骨桥蛋白(OPN)基因启动区多态性与乙型肝炎病毒相关肝细胞癌(HBV-HCC)遗传易感性的关系。【方法】225例确诊为HBV-HCC患者与200例年龄匹配的慢性乙型肝炎患者被纳入研究。OPN基因启动区3个多态性位点(-156del G/G,-443T/C和-616T/G)通过直接测序法确定基因型。【结果】HBV-HCC组-156 del G/del G基因型分布频率高于对照组(P=0.003)。HCC组-156 del G等位基因频率显著增高(P0.001)。Logistic回归分析显示等位基因-156del G是HBV-HCC的易感因素(OR=1.643,95%CI 1.249-2.161)。两组间-443T/C、-616T/G基因型分布和等位基因频率差异没有统计学意义。【结论】OPN基因启动区-156等位基因可能是中国人群HBV-HCC的易感因素。
[Abstract]:[objective] to study the association of osteopontin (OPN) gene promoter polymorphism with hepatitis B virus associated hepatocellular carcinoma (HBV-HCC). [methods] 225 patients with HBV-HCC and 200 age-matched patients with chronic hepatitis B were included in the study. -156del G / G. The genotypes of -443 T / C and -616 T / G were determined by direct sequencing. [results] the distribution frequency of -156 del G / G genotype in HBV-HCC group was higher than that in control group (P < 0.05). The allele frequency of -156 del G in P0. 003 + HCC group was significantly higher than that in HCC group (P 0. 001). Logistic regression analysis showed that allele -156del G was the predisposing factor of HBV-HCC. 95 CI 1.249-2.161. -443T / C between the two groups. There was no significant difference in the distribution of -616T / G genotype and the frequency of alleles. [conclusion] the allele -156 in the promoter region of OPN gene may be the susceptible factor of HBV-HCC in Chinese population.
【作者单位】：中山大学附属第三医院感染科;
【基金】：广东省科技计划项目(20128031800069)
【分类号】：R512.62;R735.7
【正文快照】： 原发性肝癌(hepatocellular carcinoma,HCC)是我国常见的的恶性肿瘤之一,死亡率在恶性肿瘤中居第三位[1]。值得注意的是,我国的HCC患者占全球的一半以上[2]。在我国,乙型肝炎病毒是引起HCC最主要的原因。尽管临床治疗手段取得一些进展,HCC仍保持较高的死亡率。HBV相关肝细胞癌

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