输入性恶性疟疾临床特点、治疗方案与预后的分析

发布时间：2018-01-16 16:08

本文关键词：输入性恶性疟疾临床特点、治疗方案与预后的分析　出处：《河北医药》2016年21期 　论文类型：期刊论文

【摘要】：目的分析石家庄地区输入性恶性疟疾的临床特点及治疗方案,为改善预后提供依据。方法对2007年1月至2014年1月收治的66例输入性恶性疟疾的临床特点、实验室指标、治疗方案、临床预后等进行回顾性分析。结果石家庄地区输入性恶性疟疾病例逐年增多,输入性疟疾患者临床表现多样,表现为发热、畏寒、乏力、食欲不振等,实验室检查主要为白细胞升高,血小板、红细胞、血红蛋白下降,C-反应蛋白升高,肝功能、肾功能异常。单用蒿甲醚治疗40例,联合应用蒿甲醚、双氢青蒿素哌喹片、伯氨喹治疗26例,66例患者除1例死亡,3例遗留有慢性肾衰竭外,均治愈(治愈率93.9%),疗程8~28 d,治疗后再燃1例。结论输入性恶性疟疾临床表现各异,及早确诊,及时给予抗疟原虫为主的对症支持治疗为辅的综合治疗,对提高输入性恶性疟疾的治愈率,改善预后意义重大。
[Abstract]:Objective to analyze the clinical characteristics and treatment of imported falciparum malaria in Shijiazhuang area. Methods 66 cases of imported falciparum malaria were treated from January 2007 to January 2014. Results the cases of imported falciparum malaria in Shijiazhuang area increased year by year. The clinical manifestations of imported malaria patients were various, such as fever, chills, fatigue, loss of appetite and so on. Laboratory examination showed that leukocyte increased, platelet, red blood cell, hemoglobin decreased C-reactive protein increased, liver function and renal function were abnormal. 40 cases were treated with artemether alone and combined with artemether. All of the 66 patients treated with dihydroartemisinin piperaquine and primary aminoquine were cured except for 1 death and 3 patients with chronic renal failure (the cure rate was 93.9m, the course of treatment was 8d 28 days). Conclusion the clinical manifestations of imported falciparum malaria are different, early diagnosis and timely comprehensive treatment of anti-Plasmodium parasite combined with symptomatic support therapy can improve the cure rate of imported falciparum malaria. It is of great significance to improve the prognosis.
【作者单位】：河北省石家庄市第五医院;河北省石家庄市第四医院;
【基金】：河北省医学科学研究重点课题计划(编号:ZD20140411)
【分类号】：R531.3
【正文快照】： 疟疾是由疟原虫引起经按蚊叮咬传播的寄生虫病。本病高发于非洲、东南亚等部分国家及地区,近年来,我国本土疟疾的发生率逐年减少,但随着国际贸易的日益增多,尤其是我国向东南亚、非洲等地区劳务输出的增多,输入性疟疾的发病率明显上升,2009至2014年全国疟疾疫情分析中我们看到

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