青海地区藏族慢性乙肝患者血清IP-10的测定及意义

发布时间：2018-01-16 16:16

本文关键词：青海地区藏族慢性乙肝患者血清IP-10的测定及意义　出处：《青海大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：探讨青海地区藏族慢性乙型病毒性肝炎（CHB）患者血清中干扰素诱导蛋白10（IP-10）表达水平、与CHB肝脏损害的关系及其临床意义。方法：选取在青海地区生活5年以上的藏族、除外母婴垂直传播的CHB患者40例，除外CHB以外的肝损伤因素，门诊体检健康者20例。采集空腹静脉血，分离血清。CHB患者分为轻中度组与重度组，体检健康者作为对照组。所有血清样本用双抗体夹心ELISA法检测干扰素诱导蛋白10（IP-10）表达水平。采集并记录CHB患者入院时血清谷丙转氨酶（ALT）的水平。结果：CHB患者（轻中度组及重度组）血清中IP-10水平显著高于健康组，差异有统计学意义（P0.01）。CHB患者血清IP-10水平与肝脏功能损害指标（如ALT）呈正相关关系（轻中度组r=0.458，P0.05；重度组r=0.647，P0.05）。结论：青海地区藏族慢性乙肝患者中，，IP-10同样参与了慢性乙肝的损伤过程；且血清中IP-10的升高水平与肝脏功能损害程度呈正相关关系；监测藏族CHB患者血清IP-10的变化,可考虑作为判断青海藏族CHB患者病情发展、转归及指导进一步治疗的指标之一。
[Abstract]:Objective:. To investigate the expression level of interferon inducible protein (IFN- IP-10) in serum of patients with chronic viral hepatitis B (CHB) of Tibetan nationality in Qinghai area and its relationship with liver damage of CHB and its clinical significance. Methods: 40 CHB patients who lived in Qinghai area for more than 5 years except for vertical transmission from mother to child were selected. The factors of liver injury other than CHB were excluded. Fasting venous blood was collected and serum. CHB patients were divided into mild to moderate group and severe group. All serum samples were tested for interferon inducible protein 10 (IP-10) by double antibody sandwich ELISA method. The level of serum alanine aminotransferase (alt) was collected and recorded on admission in patients with CHB. Results the level of IP-10 in the serum of the patients (mild to moderate and severe) was significantly higher than that of the healthy controls. There was a positive correlation between serum IP-10 level and liver function damage (such as alt) in patients with P0.01. CHB (P 0.05). In the severe group, the rhizoid was 0. 647% (P 0. 05). Conclusion: IP-10 is also involved in the damage process of chronic hepatitis B in Tibetan patients in Qinghai area. There was a positive correlation between the level of serum IP-10 and the degree of liver function damage. Monitoring the changes of serum IP-10 in Tibetan CHB patients can be considered as one of the indexes to judge the development of Tibetan CHB in Qinghai province and to guide the further treatment.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R512.62

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