上海市莘庄社区结核病患者药物副反应发生及其危险因素分析

发布时间：2018-01-20 14:50

本文关键词： 药物副反应结核病危险因素　出处：《中国公共卫生》2017年06期 　论文类型：期刊论文

【摘要】：目的了解上海市莘庄社区结核病患者药物副反应发生现状及其危险因素,为采取相应的干预措施提供参考依据。方法收集上海市莘庄社区2010年1月1日—2014年12月31日登记的394例结核病患者病历资料和随访信息,分析结核病患者的药物副反应情况及其发生的危险因素。结果上海市莘庄社区394例新登记结核病患者中,发生药物副反应者82例(20.81%);82例发生药物副反应的结核病患者中,肝损异常者33例(40.3%),胃肠道反应者7例(8.5%),关节肌肉痛者12例(14.6%),皮疹者23例(28.1%),视神经损伤者6例(7.3%),高胆红素血症者1例(1.2%);多因素非条件logistic回归结果显示,有合并症是上海市莘庄社区结核病患者发生药物副反应的危险因素(OR=2.166,95%CI=1.114~4.212)。结论上海市莘庄社区结核病患者药物副反应以肝损异常和皮疹为主,有合并症的结核病患者更易发生药物副反应。
[Abstract]:Objective to investigate the incidence and risk factors of side drug reactions in tuberculosis patients in Xinzhuang community in Shanghai. Methods collect the medical records and follow-up information of 394 tuberculosis patients registered in Xinzhuang community from January 1st 2010 to December 31st 2014. . Results among 394 newly registered TB patients in Xinzhuang community, 82 had side effects (20.81%). Of 82 TB patients with side effects, 33 had abnormal liver damage, 7 had gastrointestinal reactions, and 12 had joint muscle pain. There were 23 cases with rash, 6 cases with optic nerve injury, and 1 case with hyperbilirubinemia. Multivariate non-conditional logistic regression analysis showed that complications were the risk factors for side effects of TB patients in Xinzhuang community of Shanghai. Conclusion the adverse drug reactions of TB patients in Xinzhuang community in Shanghai are mainly liver lesions and rashes. The patients with complicated tuberculosis are more likely to have side effects.
【作者单位】：上海市闵行区莘庄社区卫生服务中心;复旦大学公共卫生学院;
【基金】：闵行区卫生局科研课题(2014MW65)
【分类号】：R52
【正文快照】： 结核病是全球范围内一个严重的公共卫生问题,对人类健康和社会经济发展产生巨大的威胁和挑战[1]。近年来,中国结核病疫情较为严重,不但患病和死亡例数多,耐药的患者也较多,且抗结核药物副反应形势严峻,抗结核药物副反应较多[2]、发生率较高[3],不仅增加了患者的痛苦,更使得化

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