乙型肝炎患者外周血中性粒细胞与淋巴细胞比值、红细胞分布宽度变化及意义

发布时间：2018-01-25 07:28

本文关键词： 中性粒细胞淋巴细胞红细胞分布宽度肝炎乙型肝炎　出处：《山东医药》2015年35期 　论文类型：期刊论文

【摘要】：目的观察乙型肝炎患者外周血中性粒细胞与淋巴细胞比值(NLR)、红细胞分布宽度(RDW)变化,并探讨其意义。方法 82例乙型肝炎患者按病情分为慢性乙型肝炎患者42例(A组)、慢性重型肝炎患者40例[B组,根据B组患者的NLR中位数(3.51)分为B1组(NLR≤3.51)和B2组(NLR3.51)各20例],另选45例健康体检者作为对照(C组)。使用希森美康XE-5000型血常规分析仪检测各组外周血中红细胞(RBC)、血红蛋白(Hb)、RDW、中性粒细胞的绝对数目和淋巴细胞的绝对数目,计算NLR。使用法国STAGO全自动血凝仪,采用凝固法检测凝血酶原活动度(PTA)。结果与C组比较,A组RDW升高,RBC、Hb降低(P均0.05);与C组比较,B组RDW、NLR升高,RBC、Hb降低(P均0.05);与A组比较,B组RDW、NLR升高,PTA、RBC、Hb降低(P均0.05)。82例乙型肝炎患者中PTA与NLR呈负相关(r=-0.5571,P0.5)。与B2组比较,B1组NLR降低,年龄减小(P均0.05)。结论乙型肝炎患者NLR、RDW升高,检测两指标有助于肝病病情严重程度和肝脏损害程度的判断。
[Abstract]:Objective to observe the changes of the ratio of neutrophils to lymphocytes in peripheral blood of patients with hepatitis B and the RDW of erythrocyte distribution. Methods 82 patients with hepatitis B were divided into two groups: group A (n = 42) and group A (n = 40). [Group B, according to the median NLR of group B (3.51), was divided into B1 group (20 cases) and B2 group (20 cases). Another 45 healthy persons were selected as control group C, RDW of RBC and HB in peripheral blood of each group were detected by Xishenmekang XE-5000 blood routine analyzer. The absolute number of neutrophils and the absolute number of lymphocytes were calculated using the French STAGO automatic hemagglutination apparatus. The activity of prothrombin was detected by coagulation method. Results compared with group C, RDW increased in group A and HB decreased in both groups (P 0.05). Compared with group C, RDWN NLR in group B increased and HB decreased in group B (P < 0.05). Compared with group A, RDWN NLR in group B was higher than that in group A (P < 0.05). There was a negative correlation between PTA and NLR in 82 patients with hepatitis B. Compared with B2 group, NLR in group B _ 1 was lower than that in group B _ 2. Conclusion the RDW of NLRG in patients with hepatitis B is higher than that in the control group. The detection of the two indexes is helpful to judge the severity of liver disease and the degree of liver damage.
【作者单位】：广州市中山大学附属第三医院;
【基金】：教育部第44批留学回国人员科研启动基金[教外司留(2012)9401]
【分类号】：R512.62
【正文快照】： 人类乙型肝炎病毒属于肝DNA病毒科,正嗜肝病毒属。全球约20亿人曾感染过乙肝病毒(HBV),其中3.5亿人为慢性HBV感染者,每年约有100万人死于HBV感染所致的肝衰竭、肝硬化和原发性肝细胞癌[1]。我国属HBV感染的高流行区,慢性乙型肝炎是我国常见的慢性传染病之一[2]。中性粒细胞与

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