抗结核药物不良反应发生率及其影响因素分析

发布时间：2018-01-26 10:24

本文关键词： 抗结核药不良反应发生率危险因素　出处：《中华疾病控制杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的了解肺结核患者服用抗结核固定剂量复合制剂(fixed-dose combination,FDC)致不良反应的发生情况,并探讨其影响因素,为FDC的安全使用提供政策依据。方法选取新疆乌鲁木齐市某区结核病定点防治医院接受治疗的420例初治肺结核患者,监测其疗程中抗结核药物不良反应(adverse drug reactions,ADRs)发生情况,采用单因素和多因素分析方法,研究其ADRs发生的影响因素。结果总不良反应发生率较高,为62.6%。多因素非条件Logistic回归分析显示患有糖尿病与ADRs的发生有关联,与未患糖尿病患者相比,合并糖尿病患者发生ADRs危险的OR=2.509(95%CI:1.226~5.135)。结论糖尿病患者是服用FDC致发生ADRs的高危人群。对于合并糖尿病的结核患者,治疗期间应加强相关指标检测或采用其他治疗方案。
[Abstract]:Objective to investigate the incidence of adverse reactions (ADRs) induced by fixed-dose combination of anti-tuberculosis (FDCC) in patients with pulmonary tuberculosis and to explore its influencing factors. Methods 420 primary pulmonary tuberculosis patients were selected from a designated tuberculosis prevention and control hospital in Urumqi, Xinjiang, to provide policy basis for the safe use of FDC. The incidence of adverse drug reactions (ADRs) of antituberculotic drugs was monitored and univariate and multivariate analysis methods were used. To study the influencing factors of ADRs. Results the incidence of total adverse reactions was higher. Multivariate conditional Logistic regression analysis showed that diabetes was associated with the occurrence of ADRs, compared with non-diabetic patients. ADRs risk in patients with diabetes: 2.509 / 95 CI: 1.226 / 5.135). Conclusion Diabetes mellitus is a high risk group for ADRs induced by FDC. During the course of treatment, we should strengthen the detection of relevant indicators or adopt other treatment schemes.
【作者单位】：新疆医科大学公共卫生学院流行病与卫生统计学教研室;乌鲁木齐市第一人民医院儿童保健科;乌鲁木齐市疾病预防控制中心结核病防治科;
【基金】：新疆维吾尔自治区自然科学基金(201442137-20) 新疆维吾尔自治区大学生创新基金(201510760065)
【分类号】：R521
【正文快照】： (Chin J Dis Control Prev 2017,21(2):160-163)2乌鲁木齐市第一人民医院儿童保健科,新疆乌鲁木齐8300113乌鲁木齐市疾病预防控制中心结核病防治科,新疆乌鲁木齐830026我国是结核病高负担国家之一,正规的抗结核化学治疗是控制传染源的主要途径,而抗结核治疗要求联合、足量、全

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