不同治疗方案在隐性梅毒感染患者合并皮肤病中的疗效研究

发布时间：2018-01-27 10:35

本文关键词： 隐性梅毒苄星青霉素头孢曲松　出处：《中华医院感染学杂志》2017年20期 　论文类型：期刊论文

【摘要】：目的探讨苄星青霉素联合头孢曲松钠治疗潜伏梅毒患者合并皮肤感染的疗效。方法选取2014年8月-2015年5月医院收治的隐性梅毒感染合并皮疹老年患者86例。随机分为联合组和对照组,每组43例。对照组采用苄星青霉素治疗,联合组采用苄星青霉素联合头孢曲松钠治疗。分别于治疗结束时、治疗后6个月、12个月、18个月和24个月,进行螺旋体血凝(TPPA)和梅毒快速血浆反应素(RPR)血清检查。随访24个月后进行疗效评价。治疗结束时,采集两组患者清晨空腹血检测CD_3~+、CD_4~+、CD_8~+。结果治疗结束时、治疗后6个月、12个月、18个月和24个月,联合组治愈率分别为18.60%、30.23%、51.16%、60.47%和74.42%,显著高于对照组的6.98%、9.30%、23.26%、34.88%和41.86%。治疗24个月后,联合组和对照组总有效率分别为95.35%和79.07%,差异具有统计学意义(P0.05)。治疗前,两组CD_3~+、CD_4~+、CD_8~+和CD_4~+/CD_8~+均无显著性差异。治疗结束时,联合组CD_3~+、CD_4~+、CD_4~+/CD_8~+分别为(77.95±10.45)%、(45.34±7.10)%和(1.78±0.56),均显著高于对照组的(70.89±4.24)%、(41.22±6.24)%和(1.61±0.18)(P0.05);联合组CD_8~+(25.44±6.17)%显著低于对照组(27.46±5.76)%(P0.05)。结论苄星青霉素联合头孢曲松治疗老年隐性梅毒感染并发皮肤病疗效显著,优于单用苄星青霉素治疗,可作为隐性梅毒治疗的首选方案。
[Abstract]:Objective to investigate the benzathine penicillin combined with ceftriaxone sodium in the treatment of latent syphilis curative effect of patients with skin infection. 86 cases of elderly patients with latent syphilis rash methods from August 2014 -2015 year in May admitted to the hospital infection were randomly divided into combined group and control group, 43 cases in each group. The control group was treated with benzathine penicillin treatment, treated by benzathine penicillin and ceftriaxone treatment respectively. At the end of treatment, 6 months after treatment, 12 months, 18 months and 24 months of spiral blood coagulation (TPPA) and rapid plasma reagin (RPR) serum examination. To evaluate the curative effect of follow-up 24 months after the end of treatment., the two groups were collected fasting blood to detect CD_3~+, CD_4~+, CD_8~+. results at the end of treatment, 6 months after treatment, 12 months, 18 months and 24 months, the cure rate was 18.60%, 30.23%, 51.16%, 60.47% and 74.42%, significantly higher than the control Group 6.98%, 9.30%, 23.26%, 34.88% and 41.86%. after 24 months of treatment, the combination group and control group total effective rate were 95.35% and 79.07%, the difference was statistically significant (P0.05). Before treatment, two groups of CD_3~+, CD_4~+, there were no significant differences between CD_8~+ and CD_4~+/CD_8~+. At the end of treatment, the combination group CD_3~+, CD_4~+, CD_4~+/CD_8~+ respectively (77.95 + 10.45)% and (45.34 + 7.10)% and (1.78 + 0.56), were significantly higher than those in control group (70.89 + 4.24)% and (41.22 + 6.24)% and (1.61 + 0.18) (P0.05); group CD_8~+ (25.44 + 6.17)%, significantly lower than the control group (27.46 + 5.76)% (P0.05). Conclusion benzathine penicillin combined with ceftriaxone treatment significantly associated with skin disease curative effect of senile syphilis infection, treatment is better than single Yongbian benzylpenillinum, the preferred solution can be used as a recessive syphilis treatment.

【作者单位】：济南市传染病医院皮肤科;济南市疾病预防控制中心;
【分类号】：R751;R759.14
【正文快照】： 梅毒是一种可侵犯皮肤、黏膜和内脏器官的慢性、系统性传播疾病,主要由苍白螺旋体(TP)感染引起。据世界卫生组织统计,全球每年新增1200万梅毒感染者,其中多数集中在南亚、东南亚和非洲[1]。梅毒在我国最早的记录是16世纪初,在上世纪60年代基本消失。但随着改革开放,人们对性观

【相似文献】