广西壮族自治区16岁以上高中生丙型肝炎病毒感染状况调查

发布时间：2018-02-01 04:53

本文关键词： 广西肝炎丙型慢性感染　出处：《中华疾病控制杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的了解广西壮族自治区16岁以上中学生丙型肝炎病毒(hepatitis C virus,HCV)感染状况及其相关影响因素,为丙型肝炎的预防控制提供科学的理论依据。方法采用分层整群随机抽样的方法,按地理分布从广西的玉林、南宁、百色、桂林、柳州五个地区抽取2 632名16岁以上高中生,抽静脉血5 ml,采用酶联免疫吸附测定(enzyme-linked immune absorbent assay,ELISA)方法检测抗-HCV,用描述流行病学方法研究丙肝病毒感染的流行特征,用单因素和多因素Logistic回归分析丙肝感染的相关因素。结果 2 632例样本的HCV抗体阳性率为0.84%,男生抗-HCV阳性率为0.73%(6/823),女生阳性率为0.89%(16/1 800),东部(玉林)为1.03%(9/877),西部(百色)为0.66%(3/457),中部(柳州)为1.28%(3/234),北部(桂林)为0.79%(4/509),南部(南宁)为0.54%(3/555),性别和地区差异均无统计学意义(均有P0.05)。单因素及多因素分析结果显示,公用牙刷史和有内窥镜检查是丙肝感染的高危因素(OR=3.078,95%CI:1.174~48.074,P=0.022;OR=4.182,95%CI:1.328~13.170,P=0.015)。结论广西高中生丙肝病毒感染是一个重要的公共卫生问题,学生要提高自我保护意识,拒绝共用牙刷,医疗机构要加强医疗器械的消毒,积极开展预防丙型肝炎病毒感染宣传教育,防止医源性传播。
[Abstract]:Objective to understand the the Guangxi Zhuang Autonomous Region students aged 16 of hepatitis C virus (hepatitis C virus, HCV) infection status and related influencing factors, for the prevention of hepatitis C control to provide scientific and theoretical basis. Methods by using stratified random sampling method, according to the geographical distribution of Guangxi from Yulin, Nanning, Baise, Guilin, Liuzhou five area sample of 2632 men over 16 years of senior high school students, phlebotomize 5 ml was determined by enzyme-linked immunosorbent assay (enzyme-linked immune absorbent assay, ELISA) method for detection of anti -HCV, with descriptive epidemiological method to study the epidemic characteristics of hepatitis C virus infection, regression analysis of factors associated with HCV infection by univariate and multivariate Logistic. Results the positive rate of HCV antibody in 2632 samples of 0.84% boys, anti -HCV positive rate was 0.73% (6/823), the positive rate of female was 0.89% (16/1 800), Eastern (Yulin) 1.03% (9/877), West The Department (Baise) 0.66% (3/457), central (Liuzhou) to 1.28% (3/234), North (Guilin) 0.79% (4/509), South (Nanning) to 0.54% (3/555), differences in gender and area were not statistically significant (all P0.05). The results showed univariate and multivariate analysis. The common toothbrush and history of endoscopy is high risk factors for hepatitis C infection (OR=3.078,95%CI:1.174~48.074, P=0.022; OR=4.182,95%CI:1.328~13.170, P=0.015). Conclusion the senior high school students in Guangxi of hepatitis C virus infection is an important public health problem, students should raise awareness of self-protection, refused to share the toothbrush, disinfection of medical institutions should strengthen medical instruments, actively carry out publicity and education on prevention of hepatitis C to prevent virus infection, iatrogenic transmission.

【作者单位】：广西医科大学公共卫生学院流行病与卫生统计学系;
【基金】：国家自然科学基金(81460512)
【分类号】：R512.63;R181.3
【正文快照】： 丙型病毒性肝炎(hepatitis C virus,HCV)简称丙肝,丙肝已经成为继乙肝之后的第二大病毒性肝炎,因起病隐匿,俗称“沉默杀手”。多数人感染HCV后很长时间内无明显临床症状,但是病毒会在体内持续存在,HCV感染是导致慢性肝脏疾病的主要病因之一,较易转变成慢性肝炎、肝硬化和肝

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