夫西地酸钠治疗耐甲氧西林金黄色葡萄球菌感染的Meta分析

发布时间：2018-02-13 05:43

本文关键词： 夫西地酸钠葡萄球菌金黄色甲氧西林抗药性 Meta分析　出处：《中国新药与临床杂志》2015年05期 　论文类型：期刊论文

【摘要】：目的系统评价夫西地酸钠治疗耐甲氧西林金黄色葡萄球菌(MRSA)的有效性和安全性。方法计算机检索2000年至2014年在Pub Med、Ovid全文数据库、维普中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)、相关期刊论文(CNKI)、万方等数据库公开发表的以万古霉素、替考拉宁、利奈唑胺为对照,研究夫西地酸钠治疗MRSA感染的随机对照研究。评价纳入的文献质量和提取有效数据后,采用Rev Man 5.2统计学软件进行Meta分析。结果共纳入6篇文献,1篇英文,5篇中文。Meta分析结果显示,试验组与对照组的临床有效率[RR=0.95,95%CI(0.90,1.00),P0.05]、细菌清除率[RR=0.91,95%CI(0.82,1.01),P0.05]及安全性[RR=0.83,95%CI(0.63,1.09),P0.05]均无显著差异。夫西地酸钠的不良反应发生率显著小于万古霉素[RR=0.54,95%CI(0.31,0.95),P0.05]。结论夫西地酸钠治疗MRSA感染安全有效,具有较高的临床应用价值。
[Abstract]:Objective to evaluate the efficacy and safety of sodium flusidinate in the treatment of methicillin-resistant staphylococcus aureus (MRSA). Methods A full text database of Pub Medvid from 2000 to 2014 was searched by computer. VIPM, CBM, CNKI, Wanfang and other databases, which are published in Weipu Chinese Science and Technology Journals Database, are compared with vancomycin, teicoplanin and linazolamide. To study a randomized controlled study of the treatment of MRSA infection with sodium fusidic acid. The quality of the literature included and the availability of data were evaluated. Meta analysis was carried out with Rev Man 5.2 statistical software. There was no significant difference in the clinical effective rate between the trial group and the control group [RRN 0.95C95 CIQ 0.90 1.00], bacterial clearance rate (RRN 0.9195 CI 0.82C 1.01C P 0.05) and safety (RRN 0.8395 CI 0.63C 1.09P 0.05). The incidence of adverse reactions of sodium fusidic acid was significantly lower than that of vancomycin [RRN 0.5495 CI 0.31%]. Conclusion the efficacy and safety of sodium fusidate in the treatment of MRSA infection is safe and effective, and the incidence of adverse reactions is significantly lower than that of vancomycin [RRN 0.5495 CI = 0.31% 0.31% P < 0.05], but no significant difference is found between the experimental group and the control group (P < 0.05). It has high clinical application value.
【作者单位】：平凉市人民医院;
【分类号】：R515

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