贵州省一起学校流行性脑脊髓膜炎爆发疫情的病原学鉴定和多位点序列分型研究

发布时间：2018-02-15 05:32

  本文关键词： 流行性脑脊髓膜炎 爆发 C群脑膜炎奈瑟菌 多位点序列分型　出处：《中国疫苗和免疫》2016年02期 　论文类型：期刊论文

【摘要】：目的报告一起学校流行性脑脊髓膜炎(流脑)爆发疫情的病原学特征。方法对疑似流脑病例进行流行病学调查,采集患者脑脊液和血标本及首例病例密切接触者咽拭子标本,进行病原学分离鉴定、实时荧光定量聚合酶链反应(Polymerase Chain Reaction,PCR)检测和多位点序列分型(Multi-locus Sequence Typing,MLST)分析。结果该起流脑爆发疫情由C群脑膜炎奈瑟菌引起,MLST分型为ST-4821高致病克隆群。结论该起疫情由C群脑膜炎奈瑟菌ST-4281引起,该克隆群为中国独有的高致病基因群,本结果有利于制定全省流脑防控策略。
[Abstract]:Objective to report the etiological characteristics of a school epidemic cerebrospinal meningitis (meningitis) outbreak. Methods Epidemiological investigation was carried out on suspected cases of meningitis, and samples of cerebrospinal fluid and blood and pharynx swabs of the first case in close contact were collected. Pathogenic isolation and identification, Real-time fluorescence quantitative polymerase chain reaction (PCR) detection of Polymerase Chain reaction (PCR) and multilocus Sequence typing (MLSTs) analysis showed that the outbreak was caused by Neisseria meningitidis group C, which was classified as a highly pathogenic clone of ST-4821. Caused by Neisseria meningitidis group C ST-4281, The clone was a highly pathogenic gene group unique to China, and the results were helpful for the formulation of strategies for the prevention and control of cerebrospinal meningitis in the whole province.
【作者单位】： 贵州省疾病预防控制中心;黔西南州疾病预防控制中心;
【基金】：贵州省科学技术基金(黔科合J字[2014]2106号)
【分类号】：R515.2
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本文编号：1512543