巢湖地区新布尼亚病毒感染患者的临床特点和病重相关危险因素分析

发布时间：2018-02-15 09:17

  本文关键词： 血小板减少 布尼亚病毒科感染 危险因素　出处：《中华疾病控制杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的了解安徽省巢湖地区新布尼亚病毒感染患者的临床特点和病重相关危险因素。方法回顾性分析2012年4月~2015年11月安徽医科大学附属巢湖医院确诊的发热伴血小板减少综合征布尼亚病毒(severe fever with thrombocytopenia syndrome bunyavirus,SFTSV)(简称"新布尼亚病毒")感染住院病例,采用描述流行病学方法对确诊的病例流行特征、临床特点进行分析,并用单因素Logistic回归分析与病情严重程度相关危险因素。结果安徽省巢湖地区2012-2015年共报告57例发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome,SFTS),病死率为19.3%,且该地区SFTSV感染的病例呈逐年上升趋势,而农民及高龄是重症组的高危因素;4~9月为该病流行季,发病月份主要集中在5~6月份;经单因素Logistic回归分析,发现意识障碍(OR=14.236,95%CI:1.324~152.091)、血尿(OR=2.583,95%CI:1.114~5.990)和空腹葡萄糖升高(OR=34.838,95%CI:2.113~569.427)对病情严重程度具有预测作用。结论患者一旦出现意识障碍、血尿及空腹葡萄糖升高时,提示其病情危重,应引起医护人员的足够重视。
[Abstract]:Objective to investigate the clinical characteristics and risk factors of neobonia virus infection in Chaohu area of Anhui Province. Methods the febrile patients diagnosed in Chaohu Hospital affiliated to Anhui Medical University from April 2012 to November 2015 were retrospectively analyzed. Small plate reduction syndrome Bunia virus severe fever with thrombocytopenia syndrome bunyavirusSFT virus (abbreviated as "New Bunia virus") infection in hospital cases, The epidemiological characteristics and clinical characteristics of confirmed cases were analyzed by descriptive epidemiology. Results A total of 57 cases of fever with severe fever with thrombocytopenia syndrome were reported from 2012 to 2015 in Chaohu area, Anhui Province. The cases showed an upward trend year by year. Farmers and the elderly were the high risk factors in the severe group from 4 to September, and the months of onset were mainly in May and June, and the single factor Logistic regression analysis was used to analyze the incidence of the disease. It was found that the severity of the disease was predicted by the disturbance of consciousness, I. e. 1.324C: 152.091g, hematuria: 2.583n 95CIU: 1.11440 (5.990) and fasting glucose elevation (OR34.83888.95CIW 2.1133.569.427). Conclusion once there is a disturbance of consciousness, the level of hematuria and fasting glucose is increased, which indicates that the patient is in a critical condition. Adequate attention should be paid by medical staff.
【作者单位】： 安徽医科大学附属巢湖医院感染疾病科;安徽医科大学微生物学教研室;中南大学湘雅医学院;安徽医科大学第一附属医院感染疾病科;
【基金】：国家自然科学基金(81571963)
【分类号】：R510

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