围手术期抗病毒治疗对HBV相关性肝癌手术并发症的影响

发布时间：2018-02-26 05:00

本文关键词： 肝细胞肝癌肝切除并发症抗病毒治疗　出处：《中国现代医学杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的探讨肝细胞性肝癌(HCC)围手术期抗乙型肝炎病毒(HBV)治疗对术后并发症的影响。方法选取2012年1月-2015年10月在辽宁省锦州市中心医院行外科根治术的125例HBV相关HCC患者。按术前HBV-DNA载量分为低载量组(LL)和高载量组(HL),高载量组中部分患者行抗HBV治疗(AVT),部分患者不行抗HBV治疗(UN)。比较患者术后肝功能变化、病毒载量变化、并发症情况以及与并发症相关的病理因素。结果术后患者肝功能指标先升后降,UN组各项指标下降曲线均高于LL组和AVT组。AVT组患者服药后HBV-DNA水平降低。LL组和AVT组患者并发症少于UN组,住院时间减少。多因素分析显示,Child分级、肿瘤大小以及是否抗病毒是HCC患者术后并发症的独立因素。结论 HCC术前高载量HBV-DNA患者术后并发症增加,围手术期抗病毒治疗可以减少术后并发症,促进患者恢复。
[Abstract]:Objective to investigate the effect of perioperative anti-hepatitis B virus (HBV) therapy on postoperative complications of hepatocellular carcinoma of hepatocellular carcinoma (HCC). Methods #number0# cases of HBV were selected from January 2012 to October 2015 in Jinzhou Central Hospital of Liaoning Province. Patients with HCC were divided into low load group and high load group according to HBV-DNA load before operation. Some patients in high load group were treated with anti-AVT, and some patients were not able to resist HBV. The changes of liver function after operation were compared. Viral load changes, Results the decrease curve of liver function index in patients after operation was higher than that in LL group and AVT group. AVT group had lower HBV-DNA level after taking medicine. LL group and AVT group had lower HBV-DNA level. Fewer complications than those in the UN group, Multivariate analysis showed that child grade, tumor size and antiviral activity were independent factors for postoperative complications in patients with HCC. Conclusion the postoperative complications of patients with high load HBV-DNA before and after HCC are increased. Perioperative antiviral therapy can reduce postoperative complications and promote recovery.
【作者单位】：辽宁省锦州市中心医院普外科;
【基金】：辽宁省自然科学基金(No:2105020556)
【分类号】：R735.7;R512.62

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