武威市某社区人群HBsAg携带者自发性再激活的流行病学特征

发布时间：2018-02-26 07:05

本文关键词： 医院社区肝炎表面抗原乙型流行病学研究　出处：《中华疾病控制杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的分析社区人群乙型肝炎表面抗原(hepatitis B surface antigen,HBsAg)携带者发生自发性再激活的流行病学特征,为社区人群乙型肝炎的防控和管理提供科学依据。方法在2010年9月甘肃省武威市乙型肝炎血清流行病学调查建立的HBsAg携带者队列基础上,于2012年和2014年开展随访研究,分析自发性再激活的发生情况和流行病学特征。结果随访发现,852例HBsAg携带者中共有72例发生再激活,发病密度为2 746.8/10万人年。不同性别间再激活率差异存在统计学意义(x~2=3.901,P=0.048),男性累积再激活率为10.39%,高于女性累积再激活率(6.62%)。各年龄组间再激活率也存在统计学差异(x~2=6.524,P=0.038),其中46~59岁年龄组累积再激活率最高,为11.95%。HBsAg携带者基线乙型肝炎病毒(hepatitis B virus,HBV)DNA水平不同,再激活率也不同(x~2=10.404,P=0.006),当HBV DNA基线水平1×10~5IU/ml时,累积再激活率可达14.36%。结论社区HBsAg携带者中存在一定比例的自发性再激活,其中男性、中年人群和基线HBV DNA水平较高者易发生再激活,应进一步加强HBV携带者的管控工作,对其定期进行随访监测,合理选择抗病毒治疗时机。
[Abstract]:Objective to analyze the epidemiological characteristics of spontaneous reactivation of hepatitis B surface antigen-HBsAg carriers in community population. Methods based on the seroepidemiological investigation of hepatitis B in Wuwei City of Gansu Province on September 2010, the HBsAg carrier cohort was followed up on 2012 and 2014. Results 72 cases of HBsAg carriers were found to be reactivated after follow-up, according to the analysis of the occurrence and epidemiological characteristics of spontaneous reactivation. The incidence density was 2 746.8 / 100 000 person years. There were significant differences in the reactivation rate among different genders. The accumulative reactivation rate of male was 10.39, which was higher than that of female. There was also a statistical difference in reactivation rate among different age groups. The cumulative reactivation rate was the highest in the age group of 59 years old. There were different levels of HBV DNA and different reactivation rates among HBV carriers. When the baseline level of HBV DNA was 1 脳 10 ~ 5 IUU / ml, the cumulative reactivation rate could reach 14.360.Conclusion there is a certain proportion of spontaneous reactivation in HBsAg carriers in the community, especially in male, when the baseline level of HBV DNA is 1 脳 10 ~ (5) IUU / ml, there is a certain proportion of spontaneous reactivation in HBsAg carriers in the community, especially in male, when the baseline level of HBV DNA is 1 脳 10 ~ (5) IUU / ml, the cumulative reactivation rate is 14.36%. It is easy to reactivate in middle aged people and those with high HBV DNA level in baseline. It is necessary to further strengthen the control and control of HBV carriers, follow up and monitor them regularly, and select the right time for antiviral therapy.
【作者单位】：第四军医大学军事预防医学院军队流行病学教研室;
【基金】：国家自然科学基金(81473026) 国家传染病防治科技重大专项(2012ZX10004907)
【分类号】：R512.62;R181.3

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