HBV感染与胰腺癌关系的荟萃分析

发布时间：2018-02-28 22:31

本文关键词： 胰腺癌慢性乙型肝炎　出处：《重庆医科大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：乙型肝炎病毒感染是一个全球性的健康问题。据世界卫生组织2008年统计，全世界的乙肝病毒携带者超过3.5亿人，，亚洲、太平洋地区是高发地区，全球每年因患乙肝相关性疾病死亡的人数有500,000-700,000人。胰腺癌作为一个高度恶性的肿瘤，他的致病因素，目前还不完全明确。因此，此项研究对乙肝病毒感染与胰腺癌之间的关系进行了分析。方法：检索了PUBMED,Web of knowledge, EMBASE,Cohchrane,万方、CNKI、维普全文数据库等，纳入乙肝病毒感染与胰腺癌有关的病例对照研究，并采用RevMan5.0软件对符合纳入标准的6个研究通过固定效应模型或者随机效应模型进行荟萃分析。结果：荟萃分析结果显示：胰腺癌组中乙肝表面抗原的阳性率高于健康对照组(8.87%vs5.86%, OR=1.24,95%CI=1.06-1.47, P=0.009)；乙肝表面抗原以及乙肝核心抗体阴性率胰腺癌组低于健康对照组(69.4%vs77.1%, OR=0.68,95%CI=0.51-0.92, P=0.01)；而乙肝e抗原阳性率无统计学差异（P=0.550.05）。结论：乙肝病毒感染特别是乙肝表面抗原阳性可以增加胰腺癌的发病风险。
[Abstract]:Objective: hepatitis B virus infection is a global health problem. According to the statistics of the World Health Organization in 2008, there are more than 350 million people living with hepatitis B virus in the world. There are 500, 000-700, 000 deaths per year in the world from hepatitis B related diseases. Pancreatic cancer, as a highly malignant tumor, is a cause that is not entirely clear. The study analyzed the relationship between hepatitis B virus infection and pancreatic cancer. Methods: we searched PUBMEDU Web of knowledge, EMBASE Cohchrane, Wanfang CNKI, Weip full-text database, and included in the case-control study of hepatitis B virus infection and pancreatic cancer. A meta-analysis of 6 studies that meet the inclusion criteria is carried out by using RevMan5.0 software through either the fixed effect model or the random effect model. Results: the results of meta-analysis showed that the positive rate of hepatitis B surface antigen in pancreatic cancer group was higher than that in healthy control group (8.87 vs 5.86), OR1. 2495 CIQ 1.06-1.47, P0. 009, the negative rate of hepatitis B surface antigen and hepatitis B core antibody in pancreatic cancer group was lower than that in healthy control group (69.4 vs77.1, OR0.6895CII 0.51-0.92, P0. 01), and the positive rate of HBV surface antigen and hepatitis B core antibody negative pancreatic cancer group was lower than that of healthy control group (69.4 vs77.1, OR0.6895CII 0.51-0.92). There was no statistical difference in the positive rate of hepatitis B e antigen. Conclusion: hepatitis B virus infection, especially hepatitis B surface antigen positive, can increase the risk of pancreatic cancer.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R512.62;R735.9

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