重庆市少数民族地区艾滋病抗病毒治疗工作效果研究

发布时间：2018-03-01 06:12

本文关键词： 少数民族艾滋病治疗工作效果　出处：《重庆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:了解重庆市少数民族地区高效联合抗反转录病毒治疗(HAART)开展情况,评价中默项目(二期)在重庆市少数民族地区开展后的工作效果,为制定相关政策、措施,进一步扩大HAART覆盖面、为提高HAART质量提供数据支撑。方法:选择重庆市少数民族地区的石柱县、秀山县、酉阳县、彭水县作为研究现场,采用社区干预试验研究方法。收集干预前后(2013-2015年)项目总结、疫情分析报告、参加治疗者记录等资料。采用“HAART覆盖率、病死率、随访率、1次CD4检测率、2次CD4检测率、病毒载量(VL)检测率、VL有效抑制率、有效管理率”等评价指标进行统计分析。结果:与干预前相比,中默项目(二期)干预后重庆市少数民族地区的HAART覆盖率、1次和2次CD4检测率、VL检测率和有效抑制率、有效管理率均显著提高(P0.01);干预后,HAART覆盖率和2次CD4检测率高于重庆市整体水平(P0.05),1次CD4检测率从低于重庆市整体水平上升到与重庆市整体水平持平,而VL检测率和有效抑制率、有效管理率仍低于重庆市整体水平(P0.05)。干预后,AIDS病死率明显降低(P=0.029),但仍高于重庆市整体水平。多因素logistic回归分析结果显示,开始HAART时年龄越大、静脉吸毒感染的HIV/AIDS容易脱失治疗;已婚/同居、治疗前最近3个月有AIDS相关疾病/症状的HIV/AIDS更容易维持治疗。结论:中默项目(二期)扩大治疗策略提高了重庆市少数民族地区艾滋病HAART效果,是重庆市少数民族地区艾滋病防治工作的有力补充,对HIV/AIDS的治疗起到了积极作用。
[Abstract]:Objective: to investigate the development of HAART in minority areas of Chongqing, evaluate the effect of Zhongmo project (second phase) in minority areas of Chongqing, and make relevant policies and measures. Methods: Shizhu County, Xiushan County, Youyang County, Pengshui County in minority areas of Chongqing were selected as the research site. Community intervention trial was used to collect the data of project summary, epidemic situation analysis report, record of participants in the treatment before and after intervention. "HAART coverage rate, mortality rate, follow-up rate of 1 CD4 test rate and 2 CD4 detection rate were used." The VL effective inhibition rate and effective management rate were evaluated and analyzed statistically. Results: compared with those before intervention, VL effective inhibition rate and effective management rate were compared with those before intervention. After the intervention of Zhongmo Project (second stage), the HAART coverage rate was 1 and 2 times in the minority areas of Chongqing, and the VL detection rate and the effective inhibition rate were determined. After intervention, the coverage rate of HAART and the rate of two times of CD4 detection were higher than that of the whole level of Chongqing City. The rate of CD4 detection increased from the whole level of Chongqing to the same level as the whole level of Chongqing, while the detection rate of VL and the effective inhibition rate increased from the whole level of Chongqing to that of the whole level of Chongqing. The effective management rate was still lower than the whole level of Chongqing P0.050.After intervention, the fatality rate of AIDS was significantly lower than that of Chongqing, but still higher than that of Chongqing. Multivariate logistic regression analysis showed that the older the age at the beginning of HAART, the easier it was for HIV/AIDS infected by intravenous drug abuse to be removed from treatment. Married / cohabiting, HIV/AIDS with AIDS related diseases / symptoms in the last 3 months before treatment was easier to maintain. Conclusion: the extended treatment strategy of Zhongmo Project (II) has improved the effect of HAART in minority areas of Chongqing. It is a powerful supplement to the prevention and treatment of AIDS in minority areas of Chongqing, and has played a positive role in the treatment of HIV/AIDS.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R512.91

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