慢性丙型肝炎患者糖代谢异常及其相关因素研究

发布时间：2018-03-03 06:30

本文选题：胰岛素　切入点：血糖　出处：《中华疾病控制杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的丙型肝炎病毒(hepatitis C virus,HCV)患者常常伴随胰岛素抵抗以及糖尿病发生。本研究旨在探究慢性丙型肝炎(chronic hepatitis C,CHC)患者发生血糖异常的相关因素。方法本研究共纳入1 039名未经治疗的CHC患者。研究对象人口学资料、生化检查指标及其肝脏功能和HCV病毒载量等资料均来源于句容市人民医院传染科。结果有140名(13.5%)CHC患者被诊断为糖代谢异常。身体质量指数(x~2=9.231,P=0.010)、腰围(x~2=7.984,P=0.018)、收缩压(x~2=16.366,P0.001)、舒张压(x~2=13.970,P=0.001)、丙氨酸转氨酶(alanine aminotransferase,ALT)(x~2=4.809,P=0.028)以及HCV-RNA载量(t=-3.818,P0.001)等在CHC患者糖代谢正常与异常组间的分布差异具有统计学意义。多元回归分析发现,ALT(OR=2.986,95%CI:1.171~7.615)、HCV-RNA载量(OR=2.061,95%CI:1.165~3.644)为CHC患者合并糖代谢异常的危险因素。结论 ALT、HCVRNA载量可作为CHC患者糖代谢异常的提示因子,仍需对更多临床资料以及相关基因作进一步研究以发现CHC患者发生糖代谢异常新的危险因素。
[Abstract]:Objective patients with hepatitis C virus (HCV) are often associated with insulin resistance and diabetes mellitus. The purpose of this study was to investigate the related factors of abnormal blood glucose in patients with chronic hepatitis C. methods 1 039 were included in this study. Untreated CHC patients. Demographic data of subjects in the study, Results 140 patients with CHC were diagnosed as abnormal glucose metabolism. Body mass index (BMI) was 29.231 and 0.010, waist circumference was 7.984P0.01818, systolic pressure was 216.366p 0.001, diastolic pressure was 216.366p 0.001, and so on was obtained from the infectious department of people's Hospital of Chongrong City, including biochemical examination, liver function and HCV virus load, etc. The results showed that 140 patients with CHC were diagnosed as abnormal glucose metabolism. The body mass index (BMI) was 29.231%, the waist circumference was 7.984%, and the systolic pressure was 216.366g / min, respectively. The distribution of alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, al@@. Conclusion ALTV-RNA load can be used as a warning factor for abnormal glucose metabolism in patients with CHC. More clinical data and related genes are needed to identify new risk factors for abnormal glucose metabolism in patients with CHC.
【作者单位】：南京医科大学公共卫生学院流行病学系;
【基金】：国家自然科学基金(81473029) 江苏高校优势学科建设工程资助(2014年)
【分类号】：R512.63

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