自身免疫性肝炎与病毒性肝炎的临床病理特点对照分析

发布时间：2018-03-05 20:25

本文选题：自身免疫性肝炎　切入点：病毒性肝炎　出处：《医药论坛杂志》2016年12期 　论文类型：期刊论文

【摘要】：目的探讨自身免疫性肝炎(AIH)与病毒性肝炎的临床病例特点,提高自身免疫性肝炎的早期诊断的准确率,从而减少漏诊和误诊。方法选取68例AIH患者,其中急性发病32例,慢性发病36例;再选取同期收治的70例病毒性肝炎患者,其中35例慢性乙型肝炎患者,35例急性病毒性肝炎患者,作为对照。结果在免疫学以及生化检查时,AIH患者的Y球蛋白、IgM、IgG、ALP、GGT、AST/ALT的水平明显比慢性乙型肝炎和急性病毒性肝炎患者高,且AIH的慢性发病患者的Y球蛋白水平明显比急性发病患者高(P0.05);在肝组织的病理表现上,AIH患者于慢性病毒性肝炎患者在肝组织的病理表现上比较类似,但是与急性病毒性肝炎患者容易区别。结论 AIH患者的Y球蛋白、IgM、IgG、ALP、GGT、AST/ALT的水平明显比病毒性肝炎患者高,AIH患者在肝组织的病理表现较多样,最常见的主要是以碎屑样坏死,同时伴有大量淋巴细胞浸润以及桥接坏死。肝组织学检查对于AIH的早期诊断具有非常重要的意义。
[Abstract]:Objective to investigate the clinical features of autoimmune hepatitis (AIH) and viral hepatitis, to improve the accuracy of early diagnosis of autoimmune hepatitis and to reduce missed diagnosis and misdiagnosis. Among the 70 patients with viral hepatitis treated in the same period, 35 patients with chronic hepatitis B and 35 patients with acute viral hepatitis were selected. Results the serum levels of IgMG-T / T in patients with AIH were significantly higher than those in patients with chronic hepatitis B and acute viral hepatitis, as compared with those in patients with chronic hepatitis B and acute viral hepatitis, as compared with those of patients with chronic hepatitis B and acute viral hepatitis. The level of Y globulin in chronic patients with AIH was significantly higher than that in patients with acute disease (P 0.05), and the pathological manifestations of liver tissues in patients with AIH were similar to those in patients with chronic viral hepatitis. But it is easy to distinguish from the patients with acute viral hepatitis. Conclusion the level of IgGG GGTAST / alt in patients with AIH is significantly higher than that in patients with viral hepatitis, and the pathological manifestations in liver tissues of patients with AIH are more diverse, and the most common is detrital necrosis. Liver histology is very important for the early diagnosis of AIH.
【作者单位】：郑州市第十五人民医院南院感染科;
【分类号】：R575.1;R512.6

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