夹脊穴注射糖皮质激素预防50岁以上带状疱疹后神经痛的meta分析

发布时间：2018-03-07 00:26

  本文选题：带状疱疹　切入点：带状疱疹后遗神经痛　出处：《中国中西医结合皮肤性病学杂志》2016年06期 　论文类型：期刊论文

【摘要】：目的评价夹脊穴注射糖皮质激素对预防50岁以上患者带状疱疹后遗神经痛的疗效及安全性。方法计算机检索Cochrane Library、Pub Med、EMbase、CNKI、CBM、Wan Fang和VIP(从建库至2015年10月),纳入夹脊穴注射糖皮质激素或椎旁神经阻滞与空白或安慰剂对照治疗急性带状疱疹的随机对照试验,治疗组与对照组可结合或不结合基础治疗。由2名研究者按照Cochrane Handbook标准独立评价文献质量、提取数据并交叉核对,使用Rev Man5.3软件进行Meta分析。结果共纳入4个研究,合计1 374例患者。Meta分析结果显示:6个月时PHN的发生率试验组低于对照组[RR=0.39,95%CI(0.16,0.94)];除对照组出现1例严重不良反应外,其余均未报道严重不良反应。结论基于目前的证据,夹脊穴注射糖皮质激素可能预防或降低50岁以上患者PHN的发生率,且安全较好,但尚缺乏更多高质量的研究,目前还不能得到更为可靠的结论。
[Abstract]:Objective to evaluate the efficacy and safety of injection of glucocorticoid at Jiaji acupoint in the prevention of postherpetic neuralgia in patients over 50 years old. Methods Cochrane Library Pub Medbase Cochrane Fang and VIPs were searched by computer. A randomized controlled trial of corticosteroid or paravertebral nerve block in the treatment of acute herpes zoster with blank or placebo control. The treatment group and the control group could be combined with or without basic treatment. The quality of the literature was evaluated independently by two researchers according to Cochrane Handbook standard, the data were extracted and cross-checked, and the Meta analysis was carried out using Rev Man5.3 software. The results were included in 4 studies. The results of Meta-analysis of 1 374 patients showed that the incidence of PHN in the experimental group was lower than that in the control group at 6 months [RRN 0.39 ~ 95 CI0.160.94], except for one serious adverse reaction in the control group, no severe adverse reactions were reported. Injection of glucocorticoid at Jiaji point may prevent or reduce the incidence of PHN in patients over 50 years old, and it is safe and safe, but there is still a lack of more high quality research, so it is not possible to draw a more reliable conclusion at present.
【作者单位】： 天津中医药大学;贵阳中医学院第一附属医院;天津市中医药研究院;
【分类号】：R752.12
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