抗结核药物不良反应的临床分析及白细胞下降治疗效果评价

发布时间：2018-03-07 01:39

本文选题：结核　切入点：白细胞　出处：《重庆医学》2017年16期 　论文类型：期刊论文

【摘要】：目的统计抗结核药物治疗不良反应,分析白细胞下降的影响因素,比较芪胶升白胶囊与利可君片治疗白细胞下降的效果。方法统计2014年1月至2015年11月确诊的840例肺结核患者的不良反应,分析白细胞下降的影响因素;评估比较芪胶升白胶囊(n=480)及利可君(n=360)治疗白细胞下降的疗效。结果临床医生对血常规监测不够重视(39.4%)。不良反应中肝功损害发生率最高(肝酶谱异常27.0%,胆汁酸升高8.2%)、白细胞下降次之[25.4%,Ⅰ度为主(16.9%)];女性(P=0.000)和合并肝功损害(P=0.010)可能是白细胞下降的危险因素。两种药物治疗后白细胞上升,差异有统计学意义(P=0.000)。结论白细胞下降发生率较高,女性和肝功损害者更易出现,复诊时应注意血常规监测。
[Abstract]:Objective to analyze the influence factors of leukocytopenia on the side effects of antituberculous drug therapy. Methods the adverse reactions of 840 patients with pulmonary tuberculosis from January 2014 to November 2015 were analyzed and the influencing factors of leukopenia were analyzed. To evaluate and compare the therapeutic effects of Qijiaoshengbai capsule (QJSHB 480) and rikejunn (360) in the treatment of leukopenia. Results the clinicians did not pay enough attention to blood routine monitoring. The incidence of liver function damage was the highest among the adverse reactions (hepatic enzyme spectrum abnormality 27.0 and bile acid increased). 8.2%, leukocytopenia (25.4%, mainly 16.9C), female P0. 000) and combined liver damage (P0. 010) may be the risk factors of leukopenia. Conclusion the incidence of leukocytopenia is higher in women and patients with liver dysfunction.
【作者单位】：第三军医大学第一附属医院呼吸内科;
【分类号】：R521

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