CHB患者血清DNA载量与ALT、APRI及FIB-4值的相关性研究

发布时间：2018-03-08 23:19

本文选题：慢性乙型肝炎　切入点：DNA载量　出处：《石河子大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的通过研究BeAg阳性和阴性慢性乙型肝炎(CHB)患者血清HBV DNA载量与ALT、APRI及FIB-4值的相关性,了解在不同的HBe Ag表达状态下血清HBV DNA水平对监测病情进展的不同应用价值。方法收集111例CHB患者的基本资料及血清HBV DNA载量、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、血小板(PLT)水平等血清学资料,运用公式计算出APRI及FIB-4指数值,并将丙氨酸氨基转移酶(ALT)作为炎症指标,将APRI及FIB-4指数作为肝脏纤维化指标进行相关性研究。采用SPSS21.0软件进行相关性统计分析及Graphpad Prism 5软件进行统计图绘制。结果HBeAg阴性CHB患者血清HBV DNA载量较HBeAg阳性CHB患者的低(Z=-3.684,P0.01);两组ALT及APRI的差异均无统计学意义(Z1=-0.968,P0.05;Z2=-0.808,P0.05);HBeAg阴性CHB患者FIB-4值高于HBeAg阳性CHB患者(Z=-2.266,P0.05)。HBeAg阴性CHB患者的年龄比HBeAg阳性CHB患者的大,差异有统计学意义(t=3.859,P0.01)。HBe Ag阴性CHB患者血清HBV DNA载量与ALT呈正相关(r=0.347,P0.01),与APRI呈显著正相关(r=0.648,P0.01),与FIB-4值呈显著正相关(r=0.596,P0.01);HBeAg阳性CHB患者血清HBV DNA载量与ALT、APRI及FIB-4值均无相关性(P值均大于0.05)。结论血清HBV DNA水平可较好反映出HBe Ag阴性CHB患者肝组织炎症及纤维化程度;但不能体现出HBeAg阳性CHB患者的肝组织炎症及纤维化程度。
[Abstract]:Objective to study the correlation between serum HBV DNA load and alt APRI and FIB-4 in patients with BeAg positive and negative chronic hepatitis B (CHB). To understand the value of serum HBV DNA level in monitoring the disease progression in different HBe Ag expression states. Methods the basic data and serum HBV DNA load were collected in 111 patients with CHB. Serum levels of alanine aminotransferase (alt), aspartate aminotransferase (AST) and platelets (PLT) were calculated by using the formula to calculate the values of APRI and FIB-4, and alanine aminotransferase (alt) was used as an inflammatory index. The correlation between APRI and FIB-4 index as hepatic fibrosis index was studied. SPSS21.0 software was used to analyze the correlation and Graphpad Prism 5 software was used to plot the correlation. Results the HBV DNA load in HBeAg negative CHB patients was higher than that in HBeAg positive CHB patients. There was no significant difference in ALT and APRI between the two groups (P < 0.05). The FIB-4 value of the patients with CHB was higher than that of the patients with HBeAg positive CHB. The age of patients with HBeAg-negative CHB was higher than that of patients with HBeAg CHB. There was a significant difference between serum HBV DNA load and ALT in CHB patients with negative HBe Ag and 3.859p 0.01n. HBe Ag negative patients. There was a significant positive correlation between HBV DNA load and ALT, a significant positive correlation with APRI, and a significant positive correlation with FIB-4 value. There was no significant correlation between the HBV DNA load and the values of ALT and FIB-4 in CHB patients with HBeAg positive CHB. There was no significant correlation between HBV DNA load and the values of ALT and FIB-4 in patients with HBeAg positive CHB. Conclusion the level of serum HBV DNA can well reflect the degree of liver inflammation and fibrosis in patients with HBe Ag negative CHB. But it can not reflect the degree of inflammation and fibrosis in liver tissue of HBeAg positive CHB patients.
【学位授予单位】：石河子大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R512.62

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