原发性胆汁性胆管炎-乙型病毒性肝炎重叠综合征患者临床特征分析

发布时间：2018-03-15 12:31

  本文选题：肝硬化　切入点：胆汁性　出处：《现代医药卫生》2016年22期 　论文类型：期刊论文

【摘要】：目的比较单纯原发性胆汁性胆管炎(PBC)患者、单纯乙型病毒性肝炎(乙肝)患者及PBC-乙肝重叠综合征患者的临床特点,分析并总结PBC-乙肝重叠综合征患者临床特征。方法回顾性分析从江苏省PBC协作组临床资料库(作者系协作组成员)中采用简单随机抽样方法随机筛选2007~2015年诊治并已确诊的104例单纯PBC患者(A组)、93例单纯乙肝患者(B组)、29例PBC-乙肝重叠综合征患者(C组)的临床资料,对患者年龄、性别及血清检测结果进行统计分析。结果 A、C组患者中女性明显多于男性,且A组患者中女性明显多于C组,差异均有统计学意义(P0.01);C组患者年龄明显高于B组,差异有统计学意义(P0.01),但与A组比较,差异无统计学意义(P0.05);C组患者丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总蛋白、清蛋白、免疫球蛋白(A、G、M)水平与A、B组比较,差异均无统计学意义(P0.05),但γ-谷氨酰转移酶(GGT)、碱性磷酸酶(ALP)水平明显低于A组,高于B组,差异均有统计学意义(P0.05);C组患者总胆红素、直接胆红素水平与A组比较,差异均无统计学意义(P0.05),但高于B组,差异均有统计学意义(P0.05)。结论乙肝患者经药物治疗后若ALT、AST水平降低而GGT、ALP、胆红素水平无明显改善时需进行抗线粒体抗体亚型检测,以确诊是否伴PBC。
[Abstract]:Objective to compare the clinical characteristics of patients with primary biliary cholangitis (PBC), patients with simple viral hepatitis B (HBV) and patients with PBC- hepatitis B overlap syndrome. The clinical characteristics of patients with PBC- hepatitis B overlap syndrome were analyzed and summarized. Methods A retrospective analysis was made on the clinical data base of Jiangsu Province PBC Co-operative Group (the author was a member of the Co-operative Group), who were randomly selected for diagnosis and treatment from 2007 to 2015 by using a simple random sampling method. Clinical data of 93 patients with simple hepatitis B and 29 patients with PBC- hepatitis B overlap syndrome (group C). Results the age, sex and serum levels of patients in group A were significantly higher than those in group C, and the number of women in group A was significantly higher than that in group C. the difference was statistically significant (P 0.01) and the age of group C was significantly higher than that of group B. The difference was statistically significant (P 0.01), but there was no significant difference between group A and group A in the levels of alanine aminotransferase (alt), aspartate aminotransferase (ASTT), total protein, albumin and immunoglobulin A (GN) in group A (P 0.05). There was no significant difference in the levels of total bilirubin and direct bilirubin between group A and group A, but the levels of GGTN and ALP in group A were significantly lower than those in group A and higher than those in group B. there were significant differences in total bilirubin and direct bilirubin levels between group A and group A, and the levels of total bilirubin and direct bilirubin in group C were significantly higher than those in group A. The difference was not statistically significant, but it was higher than that in group B, and the difference was statistically significant. Conclusion the anti-mitochondrial antibody subtype should be detected in patients with hepatitis B when the level of alt AST decreases and the level of GGTN ALP and bilirubin does not improve obviously after drug therapy. To confirm whether PBC was associated with PBC.
【作者单位】： 江苏大学附属昆山医院消化科;无锡市第五人民医院检验科;镇江市第三人民医院检验科;
【基金】：江苏省自然科学基金面上项目(BK20130607)
【分类号】：R512.62;R575.7
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本文编号：1616037