安徽省滁州市发热伴血小板减少综合征危险因素的病例对照研究

发布时间：2018-03-16 11:20

本文选题：发热　切入点：血小板减少　出处：《中华疾病控制杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的探讨安徽省滁州市发热伴血小板减少综合征的发病危险因素,为该病的防治工作提供科学依据。方法采用性别、年龄、住址匹配的1∶4配对病例对照研究,对安徽省滁州市的发热伴血小板减少综合征病例和选取的对照人群进行问卷调查,采用单因素和多因素的配对条件Logistic回归分析筛选危险因素。结果单因素分析中有统计学意义的变量为:发病前1月与病例接触、接触身上有蜱虫的狗、被蜱虫叮咬、生活区周围有蜱虫和工作间歇坐卧草地(均有P0.05)。进一步的多因素分析结果显示:发病前1月与病例接触(OR=5.44,95%CI:1.56~19.04,P=0.004)、接触身上有蜱虫的狗(OR=12.81,95%CI:3.20~51.25,P0.001)和被蜱虫叮咬(OR=47.25,95%CI:6.94~321.53,P0.001)是发热伴血小板减少综合征发病的主要危险因素。结论与病例接触史、接触身上有蜱虫的狗和被蜱虫叮咬是发热伴血小板减少综合征的主要发病危险因素,需加强对高发人群健康宣教和个人防护指导。
[Abstract]:Objective to investigate the risk factors of fever with thrombocytopenia syndrome in Chuzhou City, Anhui Province, and to provide scientific basis for the prevention and treatment of the disease. A questionnaire survey was conducted among fever patients with thrombocytopenia syndrome and selected control population in Chuzhou City, Anhui Province. Univariate and multivariate paired conditional Logistic regression analysis was used to screen the risk factors. Results the significant variables in univariate analysis were: contact with the case on January, contact with the dog with ticks and bite by ticks. The results of further multivariate analysis showed that the presence of ticks and intermittent sitting and lying meadows around the living area (both P0.055.05.45% CI: 1.56% 19.04% P0.004, 12.8195 CIW 3.2051.25 P0.001) and tick-bitten ORO 47.2595 CIW 321.53P0.001 were fever with platelets in the area before onset of disease (47.2595 CIW 6.94% 321.53P0.001). To reduce the main risk factors of syndrome. Conclusion the history of contact with cases, The main risk factors of fever associated with thrombocytopenia syndrome are contact with the dogs with ticks and being bitten by ticks. It is necessary to strengthen health education and personal protection guidance to the high risk population.
【作者单位】：滁州市疾病预防控制中心急性传染病防治科;江苏省疾病预防控制中心急性传染病防治所;
【基金】：国家自然科学基金(81373055,81601794) 江苏省重大新发传染病综合防控科技示范工程(BE2015714) 江苏省“六大人才高峰”A类项目(2013-WSN-061) 江苏省“科教强卫工程”青年医学人才项目(QNRC2016545)
【分类号】：R512.8

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