人类免疫缺陷病毒感染母婴传播阻断临床探讨

发布时间：2018-03-17 12:33

本文选题：人类免疫缺陷病毒　切入点：CD+T淋巴细胞计数　出处：《实用医学杂志》2015年06期 　论文类型：期刊论文

【摘要】：目的:探讨人类免疫缺陷病毒(HIV)感染母婴传播的阻断方法与效果。方法:回顾性分析2009年6月至2012年6月在我院分娩的110例HIV阳性孕妇的临床资料。通过采取抗病毒治疗、选择性剖宫产和人工喂养等措施进行母婴阻断,比较CD4+T淋巴细胞计数200个/μL组和200个/μL组的不同妊娠结局。观察婴儿出生后18个月龄以上HIV抗体情况。结果:(1)110例HIV阳性孕妇实行药物阻断102例,阻断率92.72%,分娩方式选择剖宫产106例,阻断率96.36%,112例新生儿全部实行人工喂养,阻断率100%。(2)CD4+T淋巴计数分为200个/μL组(84例)和200个/μL组(26例),CD4+T淋巴细胞计数200个/μL组中,贫血、早产和产后出血发生率均低于200个/μL组;新生儿低体重儿和FGR的发生率明显低于200个/μL组,两组对比差异有显著性。(3)112例婴幼儿均已满18个月,定期随访88例,随访率78.58%,随访的88例婴儿HIV抗体均为阴性。结论:人类免疫缺陷病毒(HIV)母婴阻断措施是控制儿童艾滋病流行的重要措施。
[Abstract]:Objective: to investigate the method and effect of blocking mother-to-child transmission of HIV infection. Methods: the clinical data of 110 HIV positive pregnant women delivered in our hospital from June 2009 to June 2012 were analyzed retrospectively. Selective cesarean section, artificial feeding and other measures to block the mother and child, CD4 T lymphocyte counts in 200 / 渭 L group and 200 / 渭 L group were compared with those in 200 / 渭 L group. The antibodies against HIV were observed at 18 months after birth. Results 102 cases of HIV positive pregnant women were blocked by drugs. The blocking rate was 92.72%. 106 cases of cesarean section were selected as the mode of delivery. The blocking rate 96.3636% and 112 cases of newborns were all artificially fed. The blocking rate was 100%. The CD4 T lymphocyte count was divided into 200 / 渭 L group (84 cases) and 200 / 渭 L group (n = 26). In 200 / 渭 L group, anemia was found. The incidence of premature delivery and postpartum hemorrhage was lower than that of 200 / 渭 L group, and the incidence of neonatal low birth weight and FGR was significantly lower than that of 200 / 渭 L group. The follow-up rate was 78.58. All the 88 infants were negative for HIV antibody. Conclusion: the blocking measures of human immunodeficiency virus (HIV) mother and child is an important measure to control the prevalence of AIDS in children.
【作者单位】：广州市第八人民医院妇产科;广州市第八人民医院感染科;
【基金】：广州市科技局立项(编号:2010J-E211)
【分类号】：R512.91

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