人苍白杆菌血流感染的临床研究

发布时间：2018-03-18 10:42

本文选题：人苍白杆菌　切入点：血流感染　出处：《中华医院感染学杂志》2015年05期 　论文类型：期刊论文

【摘要】：目的探讨人苍白杆菌血流感染患者的特点,为临床诊疗提供参考。方法回顾性分析2011年1月-2013年12月医院6例患者送检血液标本鉴定为人苍白杆菌感染的临床资料,采用VITEK-2全自动细菌鉴定分析系统及其配套的革兰阴性杆菌鉴定卡进行细菌鉴定,采用纸片扩散法进行药敏试验。结果血液标本中共检出6株人苍白杆菌,其感染患者多有严重基础疾病、存在免疫功能低下;6例患者均出现发热及C-反应蛋白升高,4例患者白细胞升高占66.7%、5例出现中性粒细胞升高占83.3%;6株人苍白杆菌对青霉素类、头孢呋辛、头孢他啶等二、三代头孢菌素以及含酶抑制剂的复合抗菌药物几乎均耐药,对亚胺培南、美罗培南、环丙沙星、左氧氟沙星、阿米卡星、米诺环素、磺胺甲VA唑/甲氧苄啶敏感性较高;治愈或好转4例,放弃治疗或死亡2例。结论人苍白杆菌感染为机会性感染,病原菌的分离和鉴定是诊断本病的关键,治疗应依据菌株的药敏结果选择合理的抗菌药物。
[Abstract]:Objective to investigate the characteristics of blood stream infection of human pallidus and to provide reference for clinical diagnosis and treatment. Methods the clinical data of 6 blood samples from January 2011 to December 2013 were analyzed retrospectively. The VITEK-2 automatic bacterial identification system and its associated gram-negative bacilli identification card were used to identify the bacteria, and the disk diffusion method was used to carry out the drug sensitivity test. Results A total of 6 strains of Bacillus pallidus were detected in blood samples. Most of the infected patients had serious basic diseases, 6 cases of hypoimmunity and 6 cases of fever and the elevation of C-reactive protein in 4 cases, the leukocyte increased in 66.7 cases, and the neutrophil increased in 5 cases (83.3%), and 6 strains of bacillus pallidus were found to be penicillins. Cefuroxime, ceftazidime and other second-and third-generation cephalosporins and complex antimicrobial agents containing enzyme inhibitors were almost resistant to imipenem, meropenem, ciprofloxacin, levofloxacin, amikacin, minocycline, The sensitivity of sulfamethazol / trimethoprim was high, 4 cases were cured or improved, 2 cases gave up treatment or died. Conclusion the infection of human pallidus is opportunistic infection, the isolation and identification of pathogenic bacteria is the key to diagnosis of this disease. Reasonable antimicrobial agents should be selected according to the drug sensitivity of the strain.
【作者单位】：解放军总医院南楼呼吸科;解放军总医院南楼检验科;
【基金】：军队保健专项基金资助项目(14BJZ0606)
【分类号】：R516

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