病毒性肝炎相关肝硬化危险因素的病例对照研究

发布时间：2018-03-18 12:27

本文选题：肝硬化　切入点：乙型肝炎　出处：《中国艾滋病性病》2017年05期 　论文类型：期刊论文

【摘要】：目的了解发生病毒性肝炎相关肝硬化的影响因素。方法2016年7-9月,选择河北、吉林、河南和陕西4省4家医院的病毒性肝炎(包括乙型和丙型肝炎)相关肝硬化患者作为病例组,按照1∶1的比例选择慢性乙型肝炎(CHB)和慢性丙型肝炎(CHC)患者作为对照组。通过问卷调查了解其社会人口学特征、病毒性肝炎病史和行为习惯等,分析影响肝硬化发生的危险因素。结果共218例病人,病毒性肝炎相关肝硬化病例109例,对照组CHB和CHC病例共109例。两组间在年龄、性别、HBV和HCV感染状况等方面无统计学差异(P0.05)。多因素Logistic回归分析结果显示,饮酒[比值比(OR)=2.13,95%可信区间(CI):1.01~4.49]和吸烟(OR=2.31,95%CI:1.04~5.16)是病毒性肝炎相关肝硬化的危险因素;受教育程度较高(OR=0.42,95%CI:0.20~0.87)、抗病毒治疗(OR=0.39,95%CI:0.20~0.75)和运动(OR=0.23,95%CI:0.07~0.82)是病毒性肝炎相关肝硬化的保护性因素。结论病毒性肝炎相关肝硬化的主要危险因素是缺乏相关知识、不能坚持抗病毒治疗、饮酒、吸烟和缺乏锻炼等不良行为习惯。应加强对CHB和CHC患者的健康教育,改变不良行为习惯,坚持抗病毒治疗,预防肝硬化的发生。
[Abstract]:Objective to investigate the influencing factors of cirrhosis associated with viral hepatitis. Methods from July to September, 2016, Hebei, Jilin Province, Hebei Province, Jilin Province, Hebei Province and Jilin Province were selected. Patients with liver cirrhosis associated with viral hepatitis (including hepatitis B and C) in 4 hospitals in Henan and Shaanxi provinces were treated as case groups. According to the ratio of 1: 1, the patients with chronic hepatitis B (CHB) and chronic hepatitis C (CHCC) were selected as the control group. Results there were 218 patients, 109 patients with viral hepatitis associated cirrhosis and 109 patients with CHB and CHC in the control group. There was no significant difference in the infection status of HCV between sex and sex (P 0.05). The results of multivariate Logistic regression analysis showed that drinking [the ratio was 2.1395% confidence interval (CI: 1.01C 4.49)] and smoking (2.3195 CI: 1.044.16) were the risk factors of viral hepatitis related cirrhosis. Highly educated CI: 0.200.20 / 0.87, antiviral therapy 0.39 / 95 CI: 0.20 0.75) and exercise 0.2395 CI: 0.07 / 0.82) are the protective factors of viral hepatitis related cirrhosis. Conclusion the main risk factors of viral hepatitis related cirrhosis are lack of relevant knowledge, inability to adhere to antiviral therapy, drinking, drinking, and so on, the main risk factors of viral hepatitis related cirrhosis are as follows: (1) the main risk factors of viral hepatitis related cirrhosis are lack of relevant knowledge, and the main risk factors of viral hepatitis related cirrhosis are lack of relevant knowledge, and the main risk factors of viral hepatitis related cirrhosis are lack of relevant knowledge. We should strengthen the health education of patients with CHB and CHC, change the bad behavior habits, adhere to antiviral therapy, and prevent the occurrence of liver cirrhosis.
【作者单位】：中国疾病预防控制中心性病艾滋病预防控制中心;
【分类号】：R512.6;R575.2

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