HIV感染者HAART中LEP、HCY的变化及临床意义

发布时间：2018-03-24 20:21

本文选题：艾滋病毒感染　切入点：高效抗逆转录病毒治疗　出处：《广西师范大学学报(自然科学版)》2015年03期

【摘要】：通过检测HIV感染者在高效抗逆转录病毒治疗(highly active anti-retroviral therapy,HAART)过程中心血管疾病(cardiovascular disease,CVD)的标志物同型半胱氨酸(homocysteine,HCY)和瘦素(leptin,LEP)的含量,判断其在HIV感染人群中对CVD的预防作用。采用酶联免疫吸附实验(ELISA)检测桂林市第三人民医院62例HIV感染者和30名健康对照组血清中LEP和HCY水平,结果显示,HIV感染治疗组血清HCY的水平明显高于未治疗组与正常对照组,差异具有统计学意义(P0.01),血清LEP在3组中无明显变化(P0.05),血清HCY与CD4+T淋巴细胞计数及TG呈正相关作用(P0.01)。可见,在HIV感染者HAART过程中,动态地检测病人血清HCY水平有助于HIV感染者并发CVD的早期预防,为HIV感染人群并发CVD提供早期预防依据。
[Abstract]:The levels of homocysteine homocysteine homocysteine (homocysteine cysteine) and leptin leptin (leptin) in HIV infected persons during high active anti-retroviral therapy (HAART) were detected. The serum levels of LEP and HCY in 62 patients with HIV infection and 30 healthy controls in the third people's Hospital of Guilin were detected by Elisa. The results showed that the level of serum HCY in the treatment group was significantly higher than that in the untreated group and the normal control group. The difference was statistically significant (P 0.01). There was no significant change in serum LEP in the three groups. There was a positive correlation between serum HCY and CD4 T lymphocyte count and TG. It can be seen that there was a positive correlation between serum HCY and CD4 T lymphocyte count and TG. Dynamic detection of serum HCY level is helpful to the early prevention of HIV infection complicated with CVD, and provides early prevention basis for HIV infection population complicated with CVD.
【作者单位】：桂林医学院附属医院感染性疾病科;军事医学科学院微生物流行病研究所;
【基金】：国家自然科学基金资助项目(81273137) 国家传染病重大专项基金资助项目(2012ZX10001-002) 广西本级技术研究与开发基金资助项目(桂财教〔2012〕98号) 桂林市科学研究与技术开发基金资助项目(20130120-18)
【分类号】：R512.91

【相似文献】