白三烯B4在结核性脑膜炎患者脑脊液中的水平及临床意义

发布时间：2018-03-26 04:05

本文选题：结核性脑膜炎　切入点：脑脊液　出处：《细胞与分子免疫学杂志》2015年08期

【摘要】：目的观察结核性脑膜炎患者脑脊液白三烯B4(LTB4)的表达,脑脊液白细胞总数、中性粒细胞数及其与病情严重程度之间的关系。方法选取临床确诊的结核性脑膜炎、隐球菌性脑膜炎、中枢神经系统白血病和非炎症性中枢神经系统疾病患者,ELISA检测患者脑脊液LTB4水平,计数患者脑脊液白细胞总数及中性粒细胞数,通过改良Rankin评分评估患者病情严重程度。比较不同疾病组脑脊液LTB4水平的差异,计算LTB4和脑脊液白细胞总数、中性粒细胞数和疾病严重程度之间的相关性。结果结核性脑膜炎患者脑脊液LTB4较隐球菌性脑膜炎、中枢神经系统白血病及非炎症性神经系统疾病组显著增高。结核性脑膜炎患者脑脊液LTB4水平和白细胞总数无相关性,和脑脊液中性粒细胞百分比及绝对数均相关。结核性脑膜炎患者病情严重程度和脑脊液LTB4水平无简单线性关系。结论结核性脑膜炎患者脑脊液LTB4水平可以作为患者脑脊液炎症反应程度的指标,但是和患者病情严重程度及预后的关系需要进一步探讨。
[Abstract]:Objective To observe the cerebrospinal fluid of patients with tuberculous meningitis (LTB4) expression of leukotriene B4, cerebrospinal fluid leukocyte count, the relationship between neutrophil count and the severity of the disease. Methods the clinical diagnosis of tuberculous meningitis, cryptococcal meningitis, central nervous system leukemia and non inflammatory diseases of central nervous system, ELISA detection cerebrospinal fluid levels of LTB4, the count of cerebrospinal fluid in patients with white blood cell count and neutrophil count by modified Rankin score in evaluating severity. Compare the differences among different disease groups CSF levels of LTB4, total LTB4 and cerebrospinal fluid white blood cells, the correlation between number of neutrophils and disease severity. The cerebrospinal fluid of patients with tuberculous meningitis LTB4 with cryptococcal meningitis, central nervous system leukemia and non inflammatory neurological diseases were significantly higher in tuberculous. There is no correlation between the level of LTB4 and cerebrospinal fluid of patients with meningitis and CSF white blood cell count, neutrophil percentage and absolute number are related. No simple linear relationship between the severity of the disease in patients with tuberculous meningitis and CSF levels of LTB4 in patients with tuberculous meningitis. Conclusion the CSF levels of LTB4 can be used as indicators of the degree of cerebrospinal fluid in patients with inflammatory reaction, but patients with serious illness and the severity and prognosis needs further investigation.

【作者单位】：第四军医大学西京医院神经内科;
【基金】：国家自然科学基金(81371334)
【分类号】：R529.3

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