隐匿性乙肝与肝细胞肝癌关系的系统评价

发布时间：2018-03-27 09:38

本文选题：隐匿性乙肝　切入点：肝细胞肝癌　出处：《重庆医科大学学报》2015年11期

【摘要】：目的:评估隐匿性乙肝(occult Hepatitis B Virus infection,OBI)是否会增加肝细胞肝癌(hepatocellular carcinoma,HCC)发生的风险。方法:2个独立的研究者分别在Medline、web of science、web of knowledge、cochrane library、Embase、Biomed Central、Elton B.Stephens.Company(EBSCO)、中国生物医学文献数据库、中国学术期刊全文数据库、万方数据库和维普中文科技期刊全文数据库中检索文献,截止搜索日期2015年4月14日,根据纳入、排除标准筛选研究隐匿性乙肝与肝细胞肝癌关系的前瞻性队列研究或病例对照研究,并对纳入文献进行质量评价和数据提取,用Review manager 5.3软件对纳入的研究进行Meta分析,并进一步分别就OBI与隐源性HCC和非显性乙肝、丙肝相关性肝细胞肝癌(hepatitis B virus surface antigen negative and antiHCV negative hepatocellular carcinoma,NBNC-HCC)的关系作了Meta分析。结果:本研究最终筛选出8个符合条件的研究,有7个回顾性研究和1个前瞻性研究。回顾性研究的Meta分析纳入的7个研究总共有1 945个对象,其中HCC有561个,因7个研究异质性较大(I2=60%),排除一个研究后,最终Meta分析结果表示OBI会增加HCC发生的风险,有统计学意义,比值比(odds ratio,OR)=9.28,95%可信区间(confidence interval,CI)=7.01~12.29,P0.001,异质性χ2=5.61,自由度(degree of freedom,df)=5,P=0.35,I2=11%。结论:本研究发现的情况表明OBI会增加HCC发生的风险,对临床有一定的指导意义。
[Abstract]:Objective: to evaluate whether occult Hepatitis B Virus infection (OBI) increases the risk of hepatocellular carcinoma (HCC). Methods: two independent researchers studied the Chinese Biomed Central Elton B. Stephens.CompanyEBSCO, in Medlineof Science of Science librarylibrary. The full text database of Chinese academic journals, the Wanfang database and the full text database of Weipu Chinese scientific and technological journals have been searched as of April 14, 2015. A prospective cohort study or case-control study on the relationship between occult hepatitis B and hepatocellular carcinoma was studied by excluding standard screening, and the quality evaluation and data extraction of the included literature were carried out. The Meta analysis of the included study was carried out with Review manager 5.3 software. Furthermore, the relationship between OBI and cryptogenic HCC, hepatitis B virus surface antigen negative and antiHCV negative hepatocellular carcinoma of NBNC-HCC was analyzed by Meta. There were 7 retrospective studies and 1 prospective study. A total of 1 945 subjects were included in the Meta analysis of the retrospective study, of which 561 were HCC. The result of Meta analysis showed that OBI increased the risk of HCC, which was statistically significant. The ratio was 9.28% 95% confidence intervalency, 7.01% 12.29% P 0.001, 蠂 2 5.61, degree of freedom of degree of freedom 5P0.35% I211111.Conclusion: the results of this study indicate that OBI increases the risk of HCC. It has certain guiding significance to clinical practice.
【作者单位】：重庆医科大学附属第一医院感染科、重庆市传染病寄生虫病学重点实验室;
【基金】：国家自然科学基金资助项目(编号:30972587)
【分类号】：R512.62;R735.7

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