南京地区无偿献血人群HBV感染情况调查

发布时间：2018-03-27 19:09

本文选题：南京地区　切入点：乙肝病毒　出处：《中国输血杂志》2017年05期

【摘要】：目的了解南京地区无偿献血者HBV感染人群分布情况,分析HBV在不同性别、年龄、城乡差异等方面的感染情况。方法选取南京红十字血液中心2015年01月-2016年01月期间金标乙肝试纸快检合格后的无偿献血者的血液标本66 742份,分别行ELISA和NAT筛查实验,对无偿献血者进行年龄、性别、教育程度、民族、婚姻状况、区域、献血情况与HBV筛查阳性结果分析。结果本研究66 742例无偿献血者中,HBV筛查总阳性225例(0.34%),ELISA阳性180例(0.27%),NAT阳性45例(0.07%);无偿献血者HBV阳性率与年龄段、性别,教育程度和婚姻状况无关(P0.05);而不同地区无偿献血者在HBV阳性检出率,城市明显高于农村(χ~2=4.496,P0.05);汉族与其他民族相比,无偿献血者HBV阳性率较高,且差别有统计学意义(χ~2=4.523,P0.05)。结论南京地区无偿献血者HBV阳性率仍有一定比例,使用NAT方法可以大大缩短"窗口期",显著降低因ELISA漏检而导致的输血后乙肝病毒感染发生率,需大力普及ELISA+NAT的应用,进一步降低输血过程中乙肝病毒的传播风险。
[Abstract]:Objective to investigate the distribution of HBV infection among unpaid blood donors in Nanjing, and to analyze HBV in different sex and age. Methods from January 2015 to January 2016, 66 742 blood samples from eligible blood donors were collected from Nanjing Red Cross Blood Center. ELISA and NAT screening tests were performed respectively. Age, sex, education, nationality, marital status, region of unpaid blood donors, Results in this study, 225 cases were positive for HBV screening in 66,742 volunteer donors. Results the positive rate of HBV, age and sex were 0.27%, 0.27%, 0.27%, 0.27%, 0.27%, 0.27%, 0.27%, 0.27% and 0.07%, respectively, among the 66,742 unpaid blood donors in this study, and the positive rate, age and sex of free blood donors were also found in this study. There was no correlation between education level and marital status, but the positive rate of HBV was significantly higher in urban than in rural areas among unpaid blood donors in different areas (蠂 2 449 6 P 0.05). The positive rate of HBV in the Han nationality was higher than that in other ethnic groups. The difference was statistically significant (蠂 ~ (2 +) 4.523) P0.050.Conclusion there is still a certain proportion of HBV positive rate in unpaid blood donors in Nanjing area. The "window period" can be greatly shortened by using NAT method, and the incidence of hepatitis B virus infection after transfusion caused by missed ELISA examination can be significantly reduced. It is necessary to popularize the application of ELISA NAT to further reduce the risk of hepatitis B virus transmission during blood transfusion.
【作者单位】：中国医学科学院北京协和医学院输血研究所;南京红十字血液中心;
【分类号】：R512.62

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