血清乳胶凝集试验对肺隐球菌病诊断的荟萃分析

发布时间：2018-04-01 04:37

  本文选题：乳胶凝集试验　切入点：肺隐球菌病　出处：《中华医院感染学杂志》2016年15期

【摘要】：目的采用荟萃分析的方法评价血清乳胶凝集试验对肺隐球菌病的诊断价值,为临床早期诊断提供参考依据。方法通过计算机检索、中国知网、万方、维普和中国生物医学文献数据库,筛选出有关血清乳胶凝集试验诊断肺隐球菌病的研究,检索日期从建库开始截止至2015年8月,采用QUADAS量表对纳入的文献进行质量评价,使用荟萃Disc 1.4软件检验异质性并合并各检验效应量,Stata 12.0软件检测发表偏倚。结果最终纳入7篇文献;荟萃分析结果显示,灵敏度为0.81,特异度为0.99,阳性似然比为63.8,阴性似然比为0.22,诊断优势比为343.74,SROC曲线下面积为0.997,Q值为0.982。结论血清乳胶凝集试验诊断肺隐球菌病有较高的灵敏度及特异度,可作为早期快速诊断肺隐球菌病的重要方法。
[Abstract]:Objective to evaluate the diagnostic value of serum latex agglutination test for pulmonary Cryptococcus pneumoniae by meta-analysis. Weip and Chinese biomedical literature database were used to screen out the diagnosis of pulmonary cryptococcosis by serum latex agglutination test. The retrieval date was from the start of construction to August 2015. The quality of the included literature was evaluated by QUADAS scale. Meta Disc 1.4 software was used to test heterogeneity and combined with each test effect quantity. Finally, the results were included in 7 articles. The results of meta-analysis showed that, The sensitivity was 0.81, the specificity was 0.99, the positive likelihood ratio was 63.8, the negative likelihood ratio was 0.22, and the diagnostic odds ratio was 343.74. The area under SROC curve was 0.997Q was 0.982.Conclusion Serum latex agglutination test has higher sensitivity and specificity in the diagnosis of pulmonary cryptococcosis. It can be used as an important method for early rapid diagnosis of pulmonary cryptococcosis.
【作者单位】： 广西医科大学第一附属医院呼吸内科;
【基金】：国家自然科学基金资助项目(81260663) 广西自然科学基金资助项目(2013GXNSFAA019166)
【分类号】：R519.4
，

本文编号：1693999