柳州市6、11型人乳头瘤病毒感染的流行病学调查

发布时间：2018-04-02 06:33

本文选题：人乳头瘤病毒　切入点：感染　出处：《广西医科大学》2017年硕士论文

【摘要】：目的人乳头瘤病毒(human papillomavirus,HPV)是生殖器部位感染率最高的病毒。本课题通过在柳州市某社区开展流行病学调查,了解本地区HPV6、11感染相关的流行病学特征;了解HPV6、11主要相关疾病尖锐湿疣的现患率及人群分布特征;掌握HPV6、11感染的危险因素,为防止HPV6、11感染造成的危害提供科学依据。方法通过在社区招募志愿者,选取符合本研究条件的志愿者作为研究对象,开展问卷调查,并对所有研究对象进行生殖器、肛门部位的检查并采用拭子采集细胞学标本。若疑为生殖器疣,并按照标准采集组织学标本。对拭子标本采用进行HPV DNA基因型检测。所有组织标本将被切为7片,前2片用于制作载玻片,进行病理学分析,剩余的切片中任选2片采用PCR进行HPV DNA基因型检测。将HPV6、11检测结果为阳性的调查对象设置为病例组(17人),在HPV6、11检测结果为阴性的研究对象中以同年龄、同性别的原则随机进行1:4配匹,选出对照组(68人)。应用EpiData3.1进行数据的录入,SPSS16.0统计软件进行统计分析。对数据采用χ2检验、条件多因素Logistic回归分析的统计方法。结果本调查共纳入研究对象1053名,对所有研究对象开展问卷调查、体检和采样,回收问卷1053份,剔除回答不全或有逻辑错误的问卷16份,有效问卷1037份。结果显示HPV6、11总感染率为1.61%,HPV6感染率为0.95%,HPV11感染率为0.85%,尖锐湿疣患病率0.38%。无论是HPV6、11感染率还是尖锐湿疣患病率,男女之间均无差异(Р0.05),HPV6、11之间的阳性率也无差异(Р0.05),HPV6、11总感染率在18-30岁段均高于31-40岁和41-55岁两个年龄段(Р0.05)。对HPV感染危险因素进行单因素χ2分析结果显示,文化程度为小学及以下(χ2=5.929,Р0.05),初次性生活年龄18岁(χ2=4.416,Р0.05),过去一年与2人以上发生性生活(χ2=24.792,Р0.05)是感染的危险因素。根据单因素分析结果,将有意义的变量进行多因素条件Logistic回归分析结果显示,初次性生活年龄18岁(OR=5.654,95%CI:1.574-20.309,P=0.008)和过去一年与2人及以上发生性生活(OR=8.538,95%CI:2.389-30.507,P=0.001)均是是HPV6、11感染的重要危险因素。结论本次调查发现男女之间尖锐湿疣患病率无差别。HPV6、11两个型别之间的感染率和总感染率在男女之间均无差别。HPV6、11感染主要集中在18-30岁的年龄段。初次性生活年龄18岁和过去一年内与2人及以上发生性生活是HPV6、11感染的重要危险因素。18-30岁是防治的重点人群,初次性生活之前接种HPV疫苗是预防HPV6、11感染的关键。
[Abstract]:Human papillomavirus (human papillomavirus HPV) is the genital area the highest infection rate of the virus. This paper carried through the epidemiological investigation in a community of Liuzhou City, related to understand the epidemiological characteristics of HPV6,11 infection in the region; understand the prevalence and major groups of disease related HPV6,11 condyloma distribution; grasp the risk factors for HPV6,11 infection in order to prevent HPV6,11 infection, the harm to provide a scientific basis. Through the recruitment of volunteers in the community, selected according to the conditions of this study volunteers as the research object, to carry out the survey, and genital for all subjects, the anus swabs and check by cytology specimens. If suspected genital warts, and learn from according to the standard of collecting tissue. Swab specimens were detected with HPV DNA genotype. All of the samples will be cut into 7 pieces, 2 pieces for the former Making slides, pathological analysis, the remaining 2 optional sections were detected by PCR HPV DNA genotype. HPV6,11 test results for the survey of the positive set for the case group (17), the HPV6,11 test results as the research object of the negative with age, the same sex randomly 1:4 matching, select the control group (68 people). The application of EpiData3.1 for data entry, SPSS16.0 statistical software for statistical analysis. The data using 2 test, regression analysis multivariate conditional Logistic. The results of this investigation were included in the study 1053 subjects to carry out questionnaire survey of all subjects, examination and sampling. 1053 copies of questionnaires, excluding the answer or logic errors of 16 questionnaires, 1037 valid questionnaires. The results showed that the total infection rate of HPV6,11 was 1.61%, the infection rate of HPV6 was 0.95%, the infection rate of HPV11 was 0.85%, the prevalence of condyloma acuminatum The rate of 0.38%. whether HPV6,11 infection rate or condyloma prevalence between men and women had no significant difference (P 0.05), but no difference between the positive rate of HPV6,11 (P 0.05), the total infection rate of HPV6,11 was 31-40 years old and 41-55 years old in two age were higher than that in the 18-30 year period (P 0.05) of HPV infected. The risk factors were analyzed by univariate chi 2 analysis showed that the culture degree of primary school and below (x 2=5.929, P 0.05), age of first sexual life at the age of 18 (x 2=4.416, P 0.05), more than 2 people over the past year and sex (x 2=24.792, P 0.05) is a risk factor for infection according to single. The results of factor analysis, regression analysis results show that the multi factor Logistic will have significant variables, age of first sexual life at the age of 18 (OR=5.654,95%CI:1.574-20.309, P=0.008) and over the past year and more than 2 people and sex (OR=8.538,95%CI:2.389-30.507, P=0.001) are important risk of HPV6,11 infection Risk factors. Conclusion the survey found that the infection rate between male and female condyloma acuminatum prevalence rate had no difference between the two types of.HPV6,11 and the total infection rate showed no significant difference between men and women in.HPV6,11 infection mainly concentrated in the age of 18-30 years old. The age of first sexual life at the age of 18 and over the past year and more than 2 people and sexual life HPV6,11 infection is an important risk factor for.18-30 years is the focus of prevention and treatment, before the first sex HPV vaccine is the key to prevent HPV6,11 infection.

【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R511;R181.3

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