我国常用IHA方法对日本血吸虫人体感染检测效能的综合评估

发布时间：2018-04-02 18:42

本文选题：日本血吸虫病　切入点：间接血凝试验　出处：《中国病原生物学杂志》2017年02期

【摘要】：目的对我国日本血吸虫人体感染检测的常用IHA方法诊断效能进行综合评估。方法在中国知网(CNKI)、万方数据(Wanfang Data)、重庆维普(VIP)、中国生物医学文献数据库、PubMed、Web of Science、Scopus和Google Scholar中检索有关间接血凝试验(IHA)诊断日本血吸虫人体感染的全部文献,采用meta分析综合评价IHA检测日本血吸虫人体感染的诊断效能。结果共有14项研究纳入最终分析,IHA法诊断日本血吸虫人体感染的灵敏度为37.6%(95%CI:32.1%~43.3%)~95.1%(95%CI:83.5%~99.4%),特异度为34.7%(95%CI:33.2%~38.2%)~91.6%(95%CI:91.6%~95.6%)。不同研究间存在异质性,采用随机效应模型加权合并的敏感度、特异度、阳性似然比和阴性似然比分别为75.6%(95%CI:73.9%~77.7%)、73%(95%CI:72.4%~73.7%)、2.877(95%CI:2.106~3.931)和0.306(95%CI:0.196~0.48)。应用加权最小二乘法、一般最小二乘法和稳健法计算得出的IHA合并准确度为0.71、0.759和0.749,合并OR值分别为5.997、9.937和8.893,3种方法拟合的IHA法SROC曲线下面积分别为0.766、0.826、0.815;合并优势比DOR值为9.41(95%CI:4.88~18.182)。散点图中散点基本对称,纳入文献发表偏倚较小。结论 IHA法对日本血吸虫人体感染诊断效能较高,是适合在向血吸虫病传播阻断乃至消除迈进中应用的适宜技术。
[Abstract]:The purpose of commonly used IHA method for diagnosis of Schistosoma japonicum infection in our human body detection were evaluated. Methods in Chinese HowNet (CNKI), Wanfang Data (Wanfang Data), Chongqing VIP (VIP), China biomedical literature database, PubMed, Web of Science, the indirect hemagglutination test and Google Scholar (search Scopus IHA diagnosis of all literature) of Schistosoma japonicum human infection, meta was used to analyze the diagnostic efficacy of comprehensive evaluation of IHA detection of Schistosoma japonicum infection. Results a total of 14 studies were included in the final analysis, IHA method, the diagnostic sensitivity of human schistosome infection was 37.6% (95%CI:32.1%~43.3%) ~95.1% (95%CI:83.5%~99.4%), the specificity was 34.7% (95%CI:33.2%~38.2%) ~91.6% (95%CI:91.6%~95.6%). The heterogeneity between studies, using a random effects model with weighted sensitivity, specificity, positive and negative likelihood ratio Were 75.6% (95%CI:73.9%~77.7%), 73% (95%CI:72.4%~73.7%), 2.877 (95%CI:2.106~3.931) and 0.306 (95%CI:0.196~0.48). By using the weighted least squares method, least square method and robust method to calculate the accuracy of IHA with 0.71,0.759 and 0.749 OR respectively, with area of IHA 5.997,9.937 and 8.893,3 SROC curve fitting method respectively. 0.766,0.826,0.815; with a value of 9.41 DOR (95%CI:4.88~18.182). The scatter plot symmetry into the publication bias is smaller. Conclusion IHA method for diagnosis of high efficacy of Schistosoma japonicum infection in the body, is suitable in the block and even eliminate the suitable technology to move forward the spread of schistosomiasis.

【作者单位】：山东省医学科学院山东省寄生虫病防治研究所;
【分类号】：R532.21

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