HBV-ACLF肝性脑病患者IL-6、IL-10、TNF-α水平表达及意义

发布时间：2018-04-03 08:35

本文选题：肝功能衰竭　切入点：肝性脑病　出处：《重庆医学》2017年09期

【摘要】：目的探讨HBV相关慢加急性肝衰竭(HBV-ACLF)合并肝性脑病(HE)患者血清白细胞介素(IL)-6、IL-10、肿瘤坏死因子α(TNF-α)水平变化及临床意义。方法选择该院2014年2月至2015年6月收治的HBV-ACLF合并HE患者40例(观察组),选择同期收治的HBV-ACLF患者35例作为对照组,比较两组患者血清IL-6、IL-10、TNF-α水平及与血氨(PA)、血清总胆红素(TBIL)、凝血酶原时间(PT)、终末期肝病模型(MELD)评分的变化规律。结果观察组IL-6、TNF-α水平均高于对照组(P0.05),两组患者IL-10水平比较差异无统计学意义(P0.05);观察组PA水平高于对照组(P0.05),但两组患者TBIL、PT水平及MELD评分比较差异无统计学意义(P0.05)。观察组IL-6、TNF-α与PA、TBIL、PT呈正相关(r=0.635、0.462,0.456、0.378,0.366、0.318,P0.05);IL-10水平与PA、TBIL、PT无相关性(r=-0.297、-0.217、-0.223,P0.05)。结论 IL-6、TNF-α水平对HBV-ACLF预后评估有重要意义,可作为ACLF患者HE发生的预警因子。
[Abstract]:Objective to investigate the changes and clinical significance of serum IL-10, tumor necrosis factor 伪 (TNF- 伪) levels in patients with HBV associated chronic and acute hepatic failure (HBV-ACLF) combined with hepatic encephalopathy (HEH).Methods from February 2014 to June 2015, 40 patients with HBV-ACLF and HE were selected (observation group) and 35 patients with HBV-ACLF treated in the same period (control group).The serum levels of IL-6, IL-10 and TNF- 伪 were compared between the two groups, and the changes of serum IL-10 TNF- 伪, serum total bilirubin (TBILA), prothrombin time (PTT) and MELD- 伪 were compared between the two groups.Results the levels of IL-6 and TNF- 伪 in the observation group were higher than those in the control group (P 0.05), but there was no significant difference in the level of IL-10 between the two groups (P 0.05), and the level of PA in the observation group was higher than that in the control group (P 0.05), but there was no significant difference in the levels of TBILP PT and MELD score between the two groups.Conclusion the level of TNF- 伪 in patients with ACLF may play an important role in evaluating the prognosis of HBV-ACLF and may be used as an early warning factor for the occurrence of HE in patients with ACLF.
【作者单位】：江西省南昌市第九医院重症肝病科;
【分类号】：R512.62;R575.3

【相似文献】