耐多药肺结核患者呼吸道感染的病原菌分布与耐药性分析

发布时间：2018-04-04 11:24

本文选题：耐多药　切入点：肺结核　出处：《中华医院感染学杂志》2016年07期

【摘要】：目的研究耐多药肺结核患者并发呼吸道感染的病原菌分布及耐药性,为合理使用抗菌药物提供参考依据。方法选取2012年12月-2015年6月医院250例肺结核发生呼吸道感染患者为研究对象,其中120例初治患者为初治组,130例复治经药敏试验确诊为耐多药肺结核患者为耐多药组;对比两组患者呼吸道感染病原菌分布及耐药性,数据采用SPSS 14.0软件进行统计分析。结果耐多药组患者检出168株病原菌,以革兰阴性菌为主,共99株占58.93%;初治组患者检出病原菌152株,以革兰阴性菌为主,共92株占60.53%;耐多药组革兰阴性菌对抗菌药物均呈现一定的耐药性,其对舒巴坦、氨曲南、头孢唑林和阿莫西林的敏感率均显著低于初治组,差异有统计学意义(P0.05)。结论耐多药肺结核患者并发呼吸道感染的病原菌对常用抗菌药物具有较强的耐药性,临床可采用碳青霉稀类抗菌药物、第四代头孢菌素、利奈唑胺与抗真菌药物联合治疗。
[Abstract]:Objective to study the distribution and drug resistance of pathogenic bacteria in multidrug resistant pulmonary tuberculosis (MDR-TB) complicated with respiratory tract infection, and to provide reference for rational use of antimicrobial agents.Methods from December 2012 to June 2015, 250 pulmonary tuberculosis patients with respiratory tract infection were selected as the study subjects, of which 120 patients were treated as the initial treatment group and 130 patients were diagnosed as multidrug resistant pulmonary tuberculosis patients by drug sensitivity test.The distribution and drug resistance of pathogenic bacteria in respiratory tract infection were compared between the two groups. The data were analyzed by SPSS 14.0 software.Results 168 strains of pathogenic bacteria were detected in multidrug resistant group, 99 strains were Gram-negative bacteria, 152 strains were Gram-negative bacteria, and 152 strains were Gram-negative bacteria in the first treatment group.A total of 92 strains accounted for 60.53.The susceptibility rates of Gram-negative bacteria to sulbactam, aztreonam, cefazolin and amoxicillin in multidrug resistant group were significantly lower than those in the control group (P 0.05).Conclusion the pathogens of multidrug resistant pulmonary tuberculosis complicated with respiratory tract infection have strong resistance to common antimicrobial agents, and can be treated with carbapenomycillin, fourth generation cephalosporin, linazolamide and antifungal drugs.
【作者单位】：新乡医学院第一附属医院结核内一科;
【基金】：河南省科技厅基金资助项目(0624410104)
【分类号】：R521

【相似文献】