HIV感染者认知功能正常时静息态脑功能连接的研究

发布时间：2018-04-05 16:03

本文选题：HIV感染　切入点：静息态　出处：《放射学实践》2017年07期

【摘要】：目的:探讨认知功能正常时HIV感染者与正常人的静息态脑功能连接情况。方法:按照入选标准搜集25例HIV感染者和27例健康志愿者作为正常对照组,比较蒙特利尔认知评估量表评分、年龄、性别、教育水平的差异。应用静息态脑功能技术以双侧大脑各区为种子点,分析两组各种子点与全脑功能连接的差异,体素P取0.005,团簇P取0.05。结果:HIV感染组与正常对照组各种子点均有统计学差异,经多重校正后有19个种子点8个脑区差异具有统计学意义。HIV感染组在以左侧额极内侧、双侧海马、双侧前扣带回、左侧顶叶、左侧丘脑、左侧梭状回的种子点与全脑的功能连接高于正常组;HIV感染组在以双侧视觉皮层枕叶、左侧岛叶区域的种子点与全脑的功能连接低于正常组;HIV感染组在以右侧运动皮层、左侧顶下叶的种子点与全脑的功能连接与正常组比较既有升高又有降低。结论:HIV感染者认知功能正常时的静息态脑功能连接与正常人有显著差异,提示HIV感染者在认知功能正常时脑功能连接可能已经出现异常,HIV病毒可能影响脑功能的连接。
[Abstract]:Aim: to investigate the connections of resting brain function between HIV infected and normal subjects with normal cognitive function.Methods: 25 patients with HIV infection and 27 healthy volunteers as normal control group were collected according to the inclusion criteria to compare the difference of Montreal Cognitive Assessment scale score, age, sex and education level.The resting brain function technique was used to analyze the difference between the two groups of subpoints and the whole brain function. The VFP was 0.005 and the cluster P was 0.05.Results there were significant differences in 8 brain regions between the infected group and the control group. After multiple correction, there were 19 seed points in 8 brain regions. The left frontal pole medial, bilateral hippocampus and bilateral anterior cingulate gyrus were found in the HIV infected group.The functional connections between the seed points of the left parietal lobe, the left thalamus, the left fusiform gyrus and the whole brain were higher than those in the normal group with HIV infection in the occipital lobe of bilateral visual cortex.The functional connections between the seed points in the left insular lobe and the whole brain were lower than those in the HIV infected group in the right motor cortex, and the functional connections between the seed points in the left inferior parietal lobe and the whole brain in the left inferior parietal lobe were higher and lower than those in the normal group.Conclusion there is a significant difference in resting brain functional connections between HIV infected patients and normal subjects when cognitive function is normal, suggesting that abnormal brain functional connections may have appeared in HIV infected persons with normal cognitive function and may affect the connections of brain functions.
【作者单位】：广东医科大学附属深圳市第三人民医院;首都医科大学附属北京佑安医院;
【基金】：北京市医院管理局临床医学发展专项经费资助(扬帆计划)(ZYLX201511) 广东省医学科学技术研究基金项目(A2015011) 深圳市科技计划资助项目(JCYJ20150402111430645)
【分类号】：R445.2;R512.91

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