布鲁氏菌病相关危险因素的Meta分析

发布时间：2018-04-08 23:38

本文选题：布鲁氏菌病　切入点：危险因素　出处：《吉林大学》2017年硕士论文

【摘要】：目的:采用Meta分析方法系统评价感染布鲁氏菌病(brucellosis)的主要危险因素及其关联强度,主要包括:(1)食用生奶制品;(2)工作时不使用防护衣或手套;(3)接触流产动物或流产物;(4)买卖牲畜;(5)处理清洗肉制品;(6)贩卖屠宰加工皮张。本文旨在探讨上述因素与布鲁氏菌病发病的相关性,为该病的预防提供循证医学依据。方法:计算机检索Pubmed、Medline、Embase、相关期刊论文(CNKI)、中国生物学文献数据库(CBM)、万方数据知识平台、中文科技期刊全文数据库—维普资讯中检索公开发表的有关布鲁氏菌病危险因素的文献。检索时限是从建库至2016年10月。根据文献纳入和排除标准,文献的研究类型为病例对照研究(case-control study)或队列研究,语种为英文和中文。对纳入文献依据Cochrane协作网上提供的医学文献质量评价方法进行文献质量评价。采用stata11.0软件进行Meta分析,计数资料二分类数据应用比值比(odds ratio,OR)及95%可信区间(confidence interval,CI)表示效应量的区间范围。采用Begger’s漏斗图和Egger’s法评估发表偏倚。结果:最终纳入16篇文献,其中包括9篇中文文献,7篇英文文献,Meta分析结果如下:(1)食用生奶制品:合并后效应量OR=2.657,95%CI(1.966-3.591),OR合并假设检验z=6.36,p0.001;(2)工作时不使用防护衣或手套:合并后效应量OR=6.328,95%CI(4.040-9.911),OR合并假设检验z=8.06,p0.001;(3)接触流产动物或流产物:合并后效应量OR=4.231,95%CI(3.104-5.766),OR合并假设检验z=9.13,p0.001;(4)买卖牲畜:合并后效应量OR=2.295,95%CI(1.598-3.296),OR合并假设检验z=4.50,p0.001;(5)处理清洗肉制品:合并后效应量OR=3.424,95%CI(1.782-6.580),OR合并假设检验z=3.59,p0.001;(6)贩卖屠宰加工皮张:合并后效应量OR=4.281,95%CI(2.586-7.087),OR合并假设检验z=5.65,p0.001。结论:布鲁氏菌病是由布鲁氏菌引起的人畜共患疾病,严重威胁着人类健康,并带来了巨大经济损失。本研究对布鲁氏菌病常见的危险因素进行了Meta分析,结果提示食用生奶制品、工作时不使用防护衣或手套、接触流产动物或流产物、买卖牲畜、处理清洗肉制品、贩卖屠宰加工皮张均为感染布鲁氏菌病的高危因素。根据以上研究结果,牧区的工作人员应在以上的操作中加强防护,达到预防该病发生的目的。
[Abstract]:Objective: to evaluate the main risk factors and the associated strength of brucellosis infection by Meta analysis.These include: 1) eating raw dairy products 2) do not use protective clothing or gloves while working (3) contact with abortive animals or miscarriages (5) handling of cleaning meat products and 6) sale of slaughtering and processing skin sheets.The purpose of this paper is to explore the correlation between the above factors and brucellosis, and to provide evidence-based medicine for the prevention of brucellosis.Methods: a computer-based search was conducted for Pubmedan Medline Embase, CNKI, CBMN, and Wanfang data knowledge platform.Full-text Database of Chinese Science and Technology Journals-search for published literature on risk factors of brucellosis.The time limit for retrieval is from the construction of the database to October 2016.According to the criteria of literature inclusion and exclusion, the type of literature was case-control study (Case-control study) or cohort study in English and Chinese.The literature quality evaluation method based on Cochrane collaborative network was used to evaluate the quality of medical literature.Stata11.0 software was used for Meta analysis. The ratio of odds odds order (OR) and 95% confidence confidence interval (95% confidence intervalescence) were used to indicate the range of effects.Publication bias was evaluated by Begger's funnel graph and Egger's method.Results: finally, 16 articles were included,Slaughtering and processing skin sheet: the combined effect quantity ORL 4.281 ~ 95 / CI = 2.586-7.087 / OR combined hypothesis test zang 5.65 (p 0.001).Conclusion: brucellosis is a zoonotic disease caused by brucellosis, which is a serious threat to human health and brings great economic losses.Meta analysis of common risk factors of brucellosis was carried out in this study. The results showed that raw dairy products should be consumed, protective clothing or gloves should not be used at work, abortive animals or miscarriages should be exposed, livestock should be bought and sold, and meat products should be cleaned.All of them were high risk factors for brucellosis.According to the above results, the staff in pastoral areas should strengthen the protection in order to prevent the occurrence of the disease.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R516.7

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