丙型肝炎病毒非结构蛋白NS2在病毒包装中的作用

发布时间：2018-04-14 13:04

本文选题：丙型肝炎病毒 + 包装　；参考：《武汉大学学报(理学版)》2015年03期

【摘要】：丙型肝炎病毒(HCV)是一种单股正链RNA病毒,是导致慢性肝炎的主要病原体之一.近年体外培养体系成功构建后HCV分子生物学的研究获得重要进展,HCV生活周期的各个步骤得到了深入研究.由于NS2蛋白既不是病毒粒子结构成分又不是病毒RNA复制必需成分,因此,近年有较多研究关注于NS2对病毒包装的影响.突变分析表明,NS2蛋白的N端保守位点及跨膜结构对病毒包装至关重要,C端蛋白酶蛋白酶结构域而非其蛋白酶活性为病毒包装所需.此外,NS2蛋白与病毒结构蛋白,非结构蛋白以及多种宿主因子存在相互作用,并在病毒包装过程中形成多种复合体,本文对这些研究进行了归纳总结.
[Abstract]:Hepatitis C virus (HCV) is a single-stranded positive RNA virus, which is one of the main pathogens leading to chronic hepatitis.Important advances in the study of HCV molecular biology after successful construction of in vitro culture system in recent years the steps of HCV life cycle have been thoroughly studied.Since NS2 protein is neither a structural component of virus particles nor an essential component of viral RNA replication, there have been more studies on the effect of NS2 on viral packaging in recent years.Mutation analysis showed that the N-terminal conserved site and transmembrane structure of NS2 protein were very important for virus packaging and the protease domain of C terminal was not the protease activity needed for virus packaging.In addition, NS2 protein interacts with virus structural protein, nonstructural protein and many host factors, and forms multiple complexes in the course of virus packaging. These studies are summarized in this paper.
【作者单位】：中国人民解放军武汉疗养院;中国科学院武汉病毒研究所;中国科学院大学;
【基金】：国家自然科学基金资助项目(31200135)
【分类号】：R512.63

【共引文献】