川南地区丙型肝炎病毒基因型的特征及其临床价值

发布时间：2018-04-16 02:25

本文选题：丙型肝炎病毒 + 基因型　；参考：《四川医学》2016年12期

【摘要】：目的了解丙型肝炎病毒(hepatitis C viral,HCV)基因型在川南地区汉族丙型肝炎患者中的分布特点及其临床意义。方法采用焦磷酸测序法对109例来我院就诊的丙型肝炎患者进行HCV基因分型并探讨不同基因型在丙型肝炎致病性的差异。结果 1106例来自川南地区HCV-RNA阳性的丙肝患者成功分型,共发现4种基因型7种亚型,按照1a、1b、2a、2b、3a、3b、6a的顺序,所占的比例依次是:2.8%、49.1%、4.7%、2.8%、3.8%、25.5%、11.3%;急性丙型肝炎、慢性丙型肝炎和丙肝后肝硬化三种临床类型的丙型肝炎均以1b型为主,其次是3b、6a型;本测序方法敏感度达到97.2%,特异性为100%;21b型患者的肝功能损害指标、HCV载量均明显高于其它亚型患者,差异有统计学意义(P0.05)。结论川南地区HCV-RNA阳性的汉族HCV感染者以1b为优势基因,3b、6a型占有较高比例;1b型HCV载量更高,可比其它亚型更容易造成丙型肝炎的慢性化、肝脏纤维化及肝功能的严重损害。
[Abstract]:Objective to investigate the distribution and clinical significance of hepatitis C virus hepatitis C virus (HCV) genotype in Han nationality patients with hepatitis C.Methods HCV genotyping was performed in 109 patients with hepatitis C by pyrosequencing and the pathogenicity of different genotypes in hepatitis C was investigated.Results 1106 HCV-RNA positive hepatitis C patients from southern Sichuan were successfully classified, and a total of 4 genotypes of 7 subtypes were found. According to the order of 1a, 1b, 2a, 2a, 2b, 3a, 3b, 6a, the proportion was 2.82.825.525.55.The proportion of the patients was 2.825.55.The proportion of patients with acute hepatitis C was 11.3a.The main clinical types of chronic hepatitis C and posthepatitic cirrhosis were type 1b, followed by type 3b 6a.The sensitivity and specificity of this sequencing method were 97.2g and 100% respectively. The HCV load in patients with liver function damage was significantly higher than that in other subtypes (P 0.05).Conclusion 1b is the dominant gene for HCV infection in Han patients with HCV-RNA positive in southern Sichuan, and the HCV load of 1b type is higher than that of other subtypes, and it is more likely to cause chronic hepatitis C, liver fibrosis and serious damage to liver function than other subtypes.
【作者单位】：西南医科大学附属医院检验科;
【分类号】：R512.63;R440

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