注射用比阿培南治疗重症细菌性感染的多中心随机对照研究及经济学评价

发布时间：2018-04-21 21:49

本文选题：重症 + 细菌性感染　；参考：《中华医院感染学杂志》2017年06期

【摘要】：目的研究注射用比阿培南治疗重症细菌性感染的效果及价值,以期用最小成本控制感染、阻断耐药菌株蔓延、降低患者经济负担。方法选取2014年2月-2016年2月新乡市4所医院重症细菌性感染者366例,分为观察组和对照组,各183例,比较患者临床指标、实验室指标、细菌学指标,评价临床疗效、细菌学疗效和不良反应及成本-效果比、敏感度。结果全分析集(FAS)病例366例(观察组和对照组各183例),符合方案标准数据集(PPS)病例364例(观察组、对照组各182例);通过痰培养、血培养和尿培养共获得病原菌株192株,观察组可评价病例94例、对照组98例;FAS中,痊愈率、总有效率、各等级细菌清除率,观察组与对照组比较,差异无统计学意义;PPS中,与对照组比较,差异无统计学意义;不良反应发生率,与对照组比较,差异无统计学意义;抗菌药物成本、C/E、敏感度,与对照组比较,差异有统计学意义(P0.05)。结论注射用比阿培南治疗重症细菌性感染效果显著,经济实惠,符合当下效果与成本兼顾的理念,值得推广。
[Abstract]:Objective to study the efficacy and value of Biapenem for injection in the treatment of severe bacterial infections, in order to control infection with minimum cost, to block the spread of drug-resistant strains and to reduce the economic burden of patients. Methods from February 2014 to February 2016, 366 patients with severe bacterial infections in 4 hospitals in Xinxiang city were divided into two groups: observation group and control group, 183 cases each. The clinical indexes, laboratory indexes and bacteriological indexes were compared, and the clinical efficacy was evaluated. Bacteriological efficacy and adverse reactions and cost-effectiveness ratio, sensitivity. Results A total of 366 cases (183 cases each in the observation group and 183 cases in the control group) and 364 cases (182 cases in the observation group and 182 cases in the control group) were analyzed. 192 strains of pathogenic bacteria were obtained by sputum culture, blood culture and urine culture. 94 cases were evaluated in the observation group and 98 cases in the control group. The cure rate, total effective rate and bacteria clearance rate of each grade were not significantly different between the observation group and the control group, but there was no significant difference between the observation group and the control group. There was no significant difference in the incidence of adverse reactions between the control group and the control group, while the cost of antimicrobial agents and the sensitivity of C / E were significantly higher than those of the control group (P 0.05). Conclusion injection is more effective than Apenem in the treatment of severe bacterial infection.
【作者单位】：新乡市第一人民医院医保办;新乡市第一人民医院呼吸内科;新乡市中心医院检验科;新乡市第一人民医院药剂科;新乡医学院第一附属医院药剂科;新乡市第二人民医院药剂科;
【基金】：河南省医学科技攻关计划基金资助项目(201602362) 新乡市重点科技攻关计划基金资助项目(ZG15035)
【分类号】：R515

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