高迁移率族蛋白B1在重型乙型肝炎中的临床意义

发布时间：2018-04-24 20:04

本文选题：重型乙型肝炎 + 高迁移率族蛋白B　；参考：《中华医院感染学杂志》2015年02期

【摘要】：目的检测重型乙型肝炎患者中高迁移率族蛋白B1(HMGB1)的表达变化,并探讨其相关的临床意义。方法收集2009年6月-2013年6月医院传染科收治的重型乙型肝炎患者82例,另取40例慢性乙型肝炎病毒感染者和40名健康体检者作为对照,根据患者病毒载量分为低病毒载量组(HBV-DNA拷贝数104/ml,21例)和高病毒载量组(HBV-DNA拷贝数106/ml,61例);根据预后将患者分为两组存活组52例和死亡组30例;HMGB1表达的测定使用ELISA法。结果对照组、慢性HBV感染组和重型乙型肝炎组HMGB1的表达分别为(12.47±1.84)、(32.65±5.79)和(76.61±8.56)μg/L,各组间差异有统计学意义(P0.01);低病毒载量组HMGB1的表达显著低于高病毒载量组(P0.01);存活组与死亡组入院时HMGB1的表达差异无统计学意义,入院后7d时存活组HMGB1表达显著升高(P0.01),但到14d时又比入院后7d时显著减低(P0.01),并低于入院时(P0.01);死亡组HMGB1的表达入院后7d以及14d HMGB1表达呈逐渐持续减低的趋势(P0.05)。结论重型乙型肝炎出现了HMGB1的异常高表达,动态监测HMGB1表达的变化有利于患者预后的评估。
[Abstract]:Objective to detect the expression of high mobility group protein B1HMGB1 in patients with severe hepatitis B and to explore its clinical significance. Methods from June 2009 to June 2013, 82 patients with severe hepatitis B were collected from the Department of Infectious Diseases, and 40 patients with chronic hepatitis B virus infection and 40 healthy controls were selected as controls. According to the viral load, the patients were divided into two groups: low viral load group (n = 21) and high viral load group (n = 61). According to the prognosis, patients were divided into two groups: survival group (n = 52) and death group (n = 30). The expression of HMGB1 was determined by ELISA method. Results the control group, The expression of HMGB1 in chronic HBV infection group and severe hepatitis B group was 12.47 卤1.84 (32.65 卤5.79) 渭 g / L and 76.61 卤8.56 渭 g / L, respectively. The HMGB1 expression in low viral load group was significantly lower than that in high viral load group (P 0.01), and the HMGB1 in survival group and death group was significantly lower than that in high viral load group. The difference was not statistically significant. On the 7th day after admission, the expression of HMGB1 in the survival group was significantly higher than that at the 7th day after admission, but at the 14th day it was significantly lower than that at the 7th day after admission and lower than that in the patient with P0.01.The expression of HMGB1 in the death group showed a tendency of decreasing gradually on the 7th and 14th days after admission. Conclusion there is abnormal high expression of HMGB1 in severe hepatitis B. dynamic monitoring of HMGB1 expression is helpful to evaluate the prognosis of patients.
【作者单位】：新乡医学院第一附属医院感染一科;
【基金】：河南省教育厅基金资助项目(200733001)
【分类号】：R512.62

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