云南省德宏州HIV感染者抗病毒治疗保持率及其影响因素分析

发布时间：2018-05-02 20:27

  本文选题：HAART维持治疗 + 脱失　； 参考：《中国健康教育》2015年12期

【摘要】：目的掌握云南省德宏州2004—2013年间HIV感染者高效抗逆转录病毒治疗的保持率及其影响因素。方法以开始抗病毒治疗时间作为进入队列的时间进行动态队列研究,计算不同随访时间HAART保持率,运用Cox比例风险回归模型分析可能的影响因素。结果 2004—2013年间共7580人入组治疗,入组者国籍以中国籍为多,占84.1%;五县市中以盈江县入组人数最多,为26.3%;入组者以男性为主,占62.2%;入组平均年龄(36.9±10.0)岁,以26~35岁为主;婚姻状况以已婚为主,占70.9%;HIV感染途径以性传播为主,占68.3%;基线CD4+T淋巴细胞计数以≤200者居多,占42.5%;入组成员的初始治疗方案中主要以齐多夫定(AZT)为主的治疗方案占据比例最大,为44.0%。截至观察期末,入组治疗后1~9年的累积保持率分别为92.2%、87.7%、85.3%、83.8%、81.8%、80.1%、78.5%、76.8%和73.8%。Cox比例风险模型多因素结果显示,研究对象国籍、所在治疗点、性别、婚姻状况、HIV感染途径、基线CD4+T淋巴细胞计数、以及初始治疗方案与HAART保持时间长短有显著关联。结论云南省德宏州HAART保持率相对较好,但随着治疗时间延长呈下降趋势。需要针对不同特征的患者采取有针对性的措施来提高依从性。
[Abstract]:Objective to understand the maintenance rate and its influencing factors of high effective antiretroviral therapy (HART) among HIV infected persons in Dehong, Yunnan province from 2004 to 2013. Methods A dynamic cohort study was conducted with the time of beginning antiviral therapy as the time of entering the queue. The retention rate of HAART was calculated at different follow-up times. The possible factors were analyzed by Cox proportional risk regression model. Results from 2004 to 2013, a total of 7580 people were admitted to the group, and the Chinese nationality was the most, accounting for 84.1%, Yingjiang County was the most in the five counties (26.3%), the male was the main group (62.2%), the average age was 36.9 卤10.0 years (2635 years). Marital status was mainly married, accounting for 70.9% of HIV infection route was mainly sexually transmitted, accounting for 68.3%, baseline CD4 T lymphocyte count 鈮，

本文编号：1835358