上海市872例抗病毒药物治疗艾滋病患者的不良反应分析

发布时间：2018-05-05 01:41

本文选题：艾滋病 + 抗逆转录病毒治疗　；参考：《中国医院药学杂志》2015年22期

【摘要】：目的:总结上海市艾滋病患者接受国家免费抗逆转录病毒治疗(anti-retroviral therapy,ART)后药物不良反应的发生情况并分析其影响因素。方法:采用回顾性研究方法,对上海市公共卫生临床中心2009年1月1日至2013年6月30日纳入免费ART项目的872例艾滋病患者进行研究,所有患者定期进行药品不良反应临床和实验室评估。结果:在治疗过程中82.80%的患者出现药物相关不良反应,常见的短期药物不良反应有消化系统症状、皮疹、骨髓抑制、中枢神经系统症状等,中长期药物不良反应有肝毒性、外周神经炎、脂肪重新分布等。齐多夫定(zidovudine,AZT)与消化系统症状、贫血,司他夫定(stavudine,D4T)与脂肪重新分布,依非韦仑(efavirenz,EFV)和奈韦拉平(nevirapine,NVP)与皮疹、肝毒性间有一定的特异关联性。结论:临床医生应针对患者特征选择适当的治疗方案以减少药物不良反应的发生,并应熟悉药物不良反应的相关处理。
[Abstract]:Objective: to summarize the incidence of adverse drug reactions (ADRs) of AIDS patients in Shanghai after receiving state free antiretroviral therapy (ART) and analyze its influencing factors. Methods: a retrospective study was conducted on 872 AIDS patients from January 1, 2009 to June 30, 2013 in Shanghai Public Health Clinical Center. All patients underwent clinical and laboratory assessments of adverse drug reactions on a regular basis. Results: during the course of treatment, 82.80% of the patients had drug-related adverse reactions. The common short-term adverse drug reactions were digestive system symptoms, rash, bone marrow depression, central nervous system symptoms, etc. Peripheral neuritis, fat redistribution, etc. Zidovudine (AZT) is associated with digestive system symptoms, anemia, stavudine D _ 4T) and fat redistribution, and is associated with rashes and hepatotoxicity, depending on non-veilent efavirenzfen (EFV) and nevirapine (NVP). Conclusion: the clinicians should select appropriate treatment plan to reduce the occurrence of adverse drug reactions, and should be familiar with the treatment of adverse drug reactions.
【作者单位】：中国人民解放军第二军医大学药事管理教研室;复旦大学上海市公共卫生临床中心;
【基金】：国家“重大新药创制”科技重大专项(编号:2012ZX09303016)
【分类号】：R512.91

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