中国2006～2014年流行性脑脊髓膜炎病例菌群分布特征及变迁趋势

发布时间：2018-05-08 23:10

本文选题：流行性脑脊髓膜炎 + 脑膜炎耐瑟菌　；参考：《中国疫苗和免疫》2015年05期

【摘要】：目的分析中国(未包括香港、澳门特别行政区和台湾地区,下同)2006~2014年不同血清群脑膜炎耐瑟菌(Neisseria meningitidis,Nm)引起的流行性脑脊髓膜炎(流脑)病例的流行病学及菌群分布和变迁特征,为预防控制流脑提供参考。方法利用2006~2014年全国法定传染病报告系统(National Notifiable Diseases Registry System,NNDRS)资料、流脑监测报告信息管理系统数据,及各省(自治区、直辖市,下同)监测工作总结报告数据,运用描述流行病学方法,采用微软公司办公软件(Microsoft Office,Excel)2007进行统计分析。结果中国2006~2014年累计报告流脑病例5 545例,年平均发病率为0.047/10万;实验室确诊病例中A、B、C、W135、其他及不可分群流脑病例分别占26.08%、10.38%、44.81%、3.54%、15.19%。全国检测出A、B、C、W135群流脑病例的省分别有29个、22个、26个、12个;1岁人群在2006~2009年以A群病例为主,2010~2014年以B群病例为主;1~6岁、7~12岁及12岁人群均以C群病例为主。A群流脑病例构成比总体呈减少趋势,C群流脑病例构成比呈先增加后减少的趋势,B群和W135群均呈上升趋势。70%的省份检出B群病例,83%的省份检出C群病例,38%的省份检出W135群病例。结论中国流脑优势流行菌群已从A群向C群变迁;流脑病例流行菌群构成正在向多元化发展。随着各地监测质量及实验室水平的不断提高,更多的实验室确诊病例将得到鉴定,各菌群流脑病例的构成和地域分布将会随之发生变化。
[Abstract]:Objective to analyze the epidemiology, microflora distribution and changes of epidemic meningitis cases in China (not including Hong Kong, Macao Special Administrative region and Taiwan, 2006 ~ 2014) caused by Neisseria meningitidis (Nm). To provide reference for prevention and control of meningitis. Methods using the data of National Notifiable Diseases Registry system NNDRSs from 2006 to 2014, the data of information management system of cerebrospinal meningitis surveillance report, and the summary data of monitoring work in provinces (autonomous regions, municipalities directly under the Central Government, the same below), the descriptive epidemiology method was used. Microsoft Office Excel 2007 was used for statistical analysis. Results from 2006 to 2014, a total of 5,545 cases of meningitis were reported in China, with an average annual incidence of 0.047 / 100 000. Among the laboratory confirmed cases, the other cases were 26.08% 10.38% (10.38%) and the other cases were 3.54% (15.19%). There are 29, 22, 26 and 12 1-year-olds in the provinces in China who have detected cases of meningitis in group A, 22 and 26, respectively. From 2006 to 2009, group A cases were the main cases among the 1-year-olds. From 2010 to 2014, group B cases were the main cases. Group C cases were the majority among 712 years old and 12 years old people. The composition ratio of group C and group W135 showed an increasing trend. 70% of the provinces detected group B cases and 83% of the provinces detected group C cases and 38% of the provinces detected W135 cases. Conclusion the dominant epidemic microflora in China has changed from group A to group C, and the composition of epidemic flora in cases of meningitis is becoming diversified. With the continuous improvement of monitoring quality and laboratory level, more laboratory confirmed cases will be identified, and the composition and geographical distribution of the cases will change.
【作者单位】：中国疾病预防控制中心免疫规划中心;中国疾病预防控制中心传染病预防控制所传染病预防控制国家重点实验室;
【分类号】：R515.2

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