耐多药结核病患者治疗依从性的影响因素分析

发布时间：2018-05-09 19:30

本文选题：电话回访 + 耐多药结核(MDR-TB)病　；参考：《中国感染控制杂志》2015年09期

【摘要】：目的探讨耐多药结核(MDR-TB)病患者出院后治疗依从性的影响因素。方法选择2011年11月—2013年1月到某结核病医院住院治疗的MDR-TB病患者,出院后定期对患者进行电话回访,询问患者服药、复查等情况,分析影响MDR-TB病患者治疗管理依从性的因素。结果 299例患者纳入研究,治疗总依从率为81.94%(245例);规律服药者249例(83.28%),服药不规律者50例(16.72%);按时复查者254例(84.95%),未按时复查者45例(15.05%);中断治疗者37例(12.37%),调查截止日仍在继续治疗者260(86.96%)。单因素分析显示:治疗依从性(包括规律服药率、按时复查率、中断治疗率和总依从率)在不同年龄、文化程度、治疗时间,以及有无不良反应的MDR-TB病患者中存在差异(均P0.05)。logistic回归分析显示:MDR-TB病患者治疗依从性与治疗时间(β=-1.47,Waldχ2=24.28,P0.05)和不良反应(β=-2.02,Waldχ2=24.24,P0.05)呈负相关,而与文化程度呈正相关(β=0.79,Waldχ2=6.50,P0.05)。结论治疗时间延长和发生不良反应会降低MDR-TB病患者治疗依从性,文化程度越高的MDR-TB病患者治疗依从性越好。
[Abstract]:Objective to investigate the influencing factors of treatment compliance in MDR-TB patients after discharge from hospital. Methods the patients with MDR-TB 's disease who were hospitalized in a tuberculosis hospital from November 2011 to January 2013 were selected. After discharge, the patients were regularly interviewed by telephone, asked for medication and rechecked, and the factors affecting the compliance of patients with MDR-TB 's disease were analyzed. Results 299 patients were included in the study, the total compliance rate of treatment was 81.94g / 245 cases, 249 cases of regular medication were 83.28m, 50 cases of irregular medication were 16.72%, 254 cases of regular reexamination were 84.95m, 45 cases of failure were 15.05 cases, 37 cases of interruption of treatment were 12.37%, the deadline of the investigation was 260m 86.96T. Univariate analysis showed that treatment compliance (including regular drug taking rate, regular reexamination rate, interrupted treatment rate and total compliance rate) was at different ages, educational level, and treatment time. There were significant differences in MDR-TB disease patients with or without adverse reactions (all P0.05).logistic regression analysis showed that there was a negative correlation between treatment compliance and duration of treatment (尾 -1.47% Wald 蠂 ~ 2 = 24.28 + P 0.05) and adverse reactions (尾 -2.02n ~ (2) Wald 蠂 ~ 2 + 24.24) P 0.05, but a positive correlation between treatment compliance and education level (尾 -0.79) Wald 蠂 ~ 2 (6.50) P0. 05). Conclusion prolonged treatment time and adverse reactions will reduce the treatment compliance of patients with MDR-TB disease. The higher the education level, the better the treatment compliance of patients with MDR-TB disease.
【作者单位】：湖南省结核病防治所;
【基金】：全球基金和WHO资助课题(CHN/10/STB/005520)
【分类号】：R52

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