人类免疫缺陷病毒相关神经病理性疼痛的病理生理学机制

发布时间：2018-05-11 23:20

  本文选题：人类免疫缺陷病毒 + gp　； 参考：《医学研究生学报》2015年08期

【摘要】：人类免疫缺陷病毒(human immunodeficiency virus,HIV)相关的感觉神经病变(HIV-related sensory neuropathy,HIV-SN)主要包含HIV感染引起的远端感觉多神经病变(distal sensory polyneuropathy,DSP)和抗逆转录病毒毒性神经病变(antiretroviral toxic neuropathies,ATN)。文中主要阐述了HIV-DSP可能与gp120诱导产生的促炎细胞因子、趋化因子、活性氧及P物质有关,而HIV-ATN则可能与应用dd C等抗逆转录病毒药物引发的线粒体毒性及小胶质细胞增生有关,并且与HIVDSP的分子机制类似,这意味着目前治疗艾滋病的常规方法可能会进一步加重患者的神经病理性疼痛。因此,开展HIV相关神经病理性疼痛的神经化学和药理机制的研究,将为其新型有效治疗药物提供新的作用靶点。
[Abstract]:HIV-related sensory neuropathysises (HIV-SNNs) mainly include distal sensory neuropathytic DSPs caused by HIV infection and antiviral toxic neuropathies ATNs. This paper mainly discusses that HIV-DSP may be related to pro-inflammatory cytokines, chemokines, reactive oxygen species and substance P induced by gp120, while HIV-ATN may be related to mitochondrial toxicity and microglial proliferation induced by ddc and other antiretrovirals. And similar to the molecular mechanism of HIVDSP, this means that the current routine treatment of AIDS may further aggravate neuropathic pain in patients. Therefore, the research on the neurochemical and pharmacological mechanism of neuropathic pain associated with HIV will provide a new target for new and effective drugs for the treatment of neuropathic pain.
【作者单位】： 南昌大学基础医学院生理学教研室;
【基金】：国家自然科学基金(81260187) 江西省教育厅科学技术研究项目(GJJ14146) 江西省青年科学基金(20114 BAB215022) 江西省研究生创新专项资金项目(YC2014-S098)
【分类号】：R512.91
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本文编号：1876091