临终患者深部念珠菌感染与白细胞和C-反应蛋白的关系研究

发布时间：2018-05-18 23:33

本文选题：临终 + 深部真菌感染　；参考：《中华医院感染学杂志》2017年22期

【摘要】：目的研究白细胞和C-反应蛋白与临终患者深部念珠菌感染的关系。方法选取2013年6月-2016年6月医院收治的确诊为深部念珠菌感染的临终患者233例及同期住院患者200例作为研究对象,根据微生物检测结果分成四组,单纯细菌感染组100例、单纯念珠菌感染组101例、念珠菌联合细菌感染组132例和微生物阴性组100例,采用免疫透射比浊法测定C-反应蛋白水平,血细胞分析仪法测定白细胞,比较各组间C-反应蛋白与白细胞水平的差异。结果 233例深部念珠菌感染患者感染以白假丝酵母为主;单纯细菌感染组、单纯念珠菌感染组和念珠菌联合细菌感染组WBC、CRP水平均明显高于微生物阴性组,与单纯细菌感染组比,单纯念珠菌感染组和念珠菌联合细菌感染组WBC、CRP水平均明显升高(P0.05);与单纯念珠菌感染组相比,念珠菌联合细菌感染组WBC、CRP水平均明显降低(P0.05);治疗7d后,单纯念珠菌感染组和念珠菌联合细菌感染组WBC及CRP水平明显升高(P0.05),与单纯念珠菌感染组相比,念珠菌联合细菌感染组WBC差异无统计学意义,CRP水平低于单纯念珠菌感染组(P0.05);相关性分析结果显示,CRP水平与深部念珠菌感染程度呈正相关,WBC水平与临终患者深部念珠菌感染病情相关性不强。结论 C-反应蛋白水平与深部念珠菌感染病情程度呈正相关,可以用于念珠菌感染病情预测。
[Abstract]:Objective to study the relationship between leucocyte and C-reactive protein and deep Candida infection in terminal patients. Methods 233 terminally diagnosed patients with deep Candida infection and 200 in-patients in the same period from June 2013 to June 2016 were selected as the study objects. According to the results of microbiological examination, the patients were divided into four groups: 100 cases of bacterial infection group. 101 cases of Candida simplex infection group, 132 cases of candida combined bacterial infection group and 100 cases of microorganism negative group were studied. The level of C-reactive protein was measured by immuno-transmission turbidimetry, and white blood cell was measured by blood cell analyzer. To compare the level of C-reactive protein and white blood cell in each group. Results 233 patients with deep Candida albicans were infected mainly by Candida albicans, and the levels of WBC CRP in bacterial infection group, Candida simplex infection group and Candida monilidii combined bacterial infection group were significantly higher than those in microorganism negative group, and were higher than those in pure bacterial infection group. The levels of WBCU CRP in Candida simplex infection group and Candida bacillus combined bacterial infection group were significantly higher than those in Candida simplex infection group, and WBCU CRP level in Candida and bacterial infection group were significantly lower than that in Candida simplex infection group, and after 7 days of treatment, WBCU CRP level in Candida monilidii combined bacterial infection group was significantly lower than that in Candida infection group. The levels of WBC and CRP in the Candida simplex infection group and the Candida combined bacterial infection group were significantly higher than those in the pure Candida infection group. The level of WBC in Candida and bacterial infection group was lower than that in Candida simplex infection group P0.05.The correlation analysis showed that there was a positive correlation between WBC level and the degree of deep Candida infection in dying patients. There was no strong correlation between the condition of bead infection and the disease. Conclusion the level of C-reactive protein is positively correlated with the severity of deep Candida infection and can be used to predict the disease of Candida infection.
【作者单位】：河南省南阳市第二人民医院检验科;河南省南阳市第二人民医院内科;河南省南阳市第二人民医院神经内科;河南省南阳市第二人民医院输血科;
【分类号】：R446.1;R519.3

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